About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Strong Influence of the Cardiovascular System on Alzheimer’s Disease

by Anjali Aryamvally on March 18, 2018 at 2:46 PM
Font : A-A+

Strong Influence of the Cardiovascular System on Alzheimer’s Disease

Anxiety and problems with blood vessels present a close relationship with Alzheimer's disease, shows study for the first time. The study conducted at the Institute of Neuroscience at the Universitat Autňnoma de Barcelona (INc-UAB) is published in the Journal of Alzheimer's Disease.

The study, conducted with mice provides new data in an emerging line of research related to this pathology, which expands the current research focus on neuroscience to include explorations which go beyond the brain and incorporate the cardiovascular system.

Advertisement


"Vascular disease resulting from oxidative stress and inflammation is an emerging concept in the study of Alzheimer's disease which is gaining clinical interest, given that subsequent cardiovascular insufficiency can alter the blood flow distribution to different organs and tissues, including the brain, which can worsen a pathology related to this type of dementia", highlights Dr Francesc Jiménez-Altayó, researcher at the Department of Pharmacology, Therapeutics and Toxicology and lead author of the paper.

The research, directed by Dr Lydia Giménez-Llort, Director of the Unit of Medical Psychology at the UAB Department of Psychiatry and Forensic Medicine, provides the first evidence that mice of advanced ages suffering from Alzheimer's disease present substantial alterations in small blood vessels, which are essential in nourishing different organs and tissues and in the regulation of blood pressure.
Advertisement

"The study specifically demonstrates that the sex of the mice is a determining factor. It is specifically the female mice which present more pronounced vascular alterations, suggesting that women of advanced ages with Alzheimer's disease may suffer more from cardiovascular malfunctions", says Dr Frances Jiménez-Altayó.

The characteristics of small arteries were studied under different physiological conditions. Further research revealed that these vascular changes appear in both the vascular structure and function, which suggests an abnormal distribution in peripheral blood flow.

Researchers also assess animal behaviour to determine effects at cognitive and emotional level. This allowed them to discover the existence of a strong relation between the vascular parameters analysed - structure, elasticity, function - and different patterns of anxiety in mice models of Alzheimer's, but also in mice ageing normally.

"Although we must be cautious with these results, the correlation of behaviours proposes the existence of direct or indirect relations between the conduct and the function of peripheral arteries. These interactions may be able to explain the anomalies of the neuro-immuno-endocrine system in charge of regulating the performance of different organs and tissues, which we already described in previous studies using male and female mice in initial and advanced stages of the disease", emphasises Dr Lydia Giménez-Llort.

"In addition, the fact that the study also provides evidence indicating a clear relation between different variables which make up anxious behaviour in animals and properties of peripheral blood vessels is a discovery containing important implications which surpass the area of research into Alzheimer's disease", she concludes.



Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

Link Between Sleep Apnea and Cognitive Decline
Researchers are working on new strategies and solutions for sleep apnea to ward off a range of health risks including cognitive decline.
Softening Stem Cells Enhances Hair Growth Potential
The scientists discovered that when the stem cells in the hair follicle are made softer, they have a higher chance of growing hair.
Potential New Strategy for Ischemic Stroke Discovered
A combinatorial therapy provided promising beneficial results among people with ischemic stroke.
Is Speech Therapy the Answer to Voice Problems in Parkinson's Disease Patients
In Parkinson's disease patients voice disorders are quite common. A new combination therapy had greater effects on the voice.
 New Insights into How the Immune System Responds to Spinal-Cord Injuries
New study findings delineate how aging affects the immune response following Spinal cord injury (SCI) and highlight the participation of the spinal cord meninges in repair.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Strong Influence of the Cardiovascular System on Alzheimer’s Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests