About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Stem Cell Therapy Used in US for Treating Neuroblastoma in Children More Toxic Than European or Egyptian Regimens

by Kathy Jones on April 26, 2013 at 9:00 PM
Font : A-A+

 Stem Cell Therapy Used in US for Treating Neuroblastoma in Children More Toxic Than European or Egyptian Regimens

A new study to be presented at the 26th annual meeting of the American Society of Pediatric Hematology Oncology in Miami suggests that the current stem cell transplant regimens to treat advanced neuroblastoma in children in the United States is more toxic compared to the regimens used in Europe and Egypt.

This and other research informed the recent decision of the Children's Oncology Group (COG) to switch to the busulfan-based regimen used for years in Europe and Egypt, said senior author Leslie E. Lehmann, MD, clinical director of pediatric stem cell transplantation at Dana-Farber/Children's Hospital Cancer Center (DF/CHCC) in Boston.

Advertisement

Both approaches to high-risk neuroblastoma employ high doses of chemotherapy to eradicate cancer cells followed by infusion of the patient's previously collected stem cells to allow the patient to recover more quickly and safely. Since 2007, physicians at DF/CHCC and others in the Children's Oncology Group had been using a combination of high-dose carboplatin, etoposide, and melphalan to prepare patients for transplant, said Lehmann. European centers have preferred busulfan and melphalan over the platinum-based regimen.

"We have had a long-standing collaboration with Children's Cancer Hospital Egypt in Cairo, which is under the leadership of senior author Dr. Alaa Elhaddad," Lehmann said. "We decided to compare the toxicities in patients who received care that was very similar except for the drugs used in the preparative regimen."
Advertisement

"We found there was no difference in survival, but our regimen was associated with more liver and kidney toxicity and more bloodstream infections," she noted. "This was very useful information as COG contemplated switching to the European approach."

In addition to the idea of using toxicity data to choose between approaches of similar efficacy, Lehmann noted, "This study demonstrates you can have true collaboration between transplant centers located in very different parts of the world."

First author of the study is Yasser Elborai, MD, of the Children's Cancer Hospital Egypt.

DF/CHCC used no outside funding for its research for this study.

--Written by Richard Saltus, Dana-Farber/Children's Hospital Cancer Center.

Dana-Farber/Children's Hospital Cancer Center
Since 1947, Boston Children's Hospital and Dana-Farber Cancer Institute have provided comprehensive care for children and adolescents with cancer through Dana-Farber/Children's Hospital Cancer Center. The two Harvard Medical School affiliates share a clinical staff that delivers inpatient care at Boston Children's and outpatient therapies at Dana-Farber's Jimmy Fund Clinic. The Boston Children's inpatient pediatric cancer service has 33 beds, including 13 designated for stem cell transplant patients.

Boston Children's is also the site of DF/CHCC inpatient clinical translational research in pediatric malignancies and has long supported the operation of an effective and productive stem cell transplant service. It has a long history of investment in and support of both clinical and basic cancer research, with more than $7.3 million in National Cancer Institute research support and 47,000 square feet of space devoted to cancer research. It is a recognized center of excellence in angiogenesis, cellular/molecular immunology, cancer genetics, and molecular signaling research.
Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Amoebic Dysentery Height and Weight-Kids Genetics and Stem Cells Reiki and Pranic Healing Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Stem Cells 

Recommended Reading
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Bone Marrow Aspiration and Biopsy
Bone marrow biopsy and aspiration is the removal of some bone marrow tissue for diagnosis and ......
Amoebic Dysentery
Amoebic dysentery or amoebiasis is an infection of the intestine that causes diarrhoea most frequent...
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)