Statins can Now Help Treat Lung Disease Too

by Hannah Joy on  August 9, 2018 at 9:21 AM Drug News
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Statins, usually help in treating cardiovascular diseases. But, a new study shows that they can also help treat people suffering with severe lung disease, as they lower cholesterol levels.
Statins can Now Help Treat Lung Disease Too
Statins can Now Help Treat Lung Disease Too

In Pulmonary Alveolar Proteinosis (PAP), air sacs in the lungs clog up with a thick substance called surfactant. The findings, led by Bruce Trapnell, from the Cincinnati Children's Hospital in the US, showed that the main culprit was cholesterol.

PAP has been linked to disruption of cell regulation by a molecule called granulocyte-macrophage colony stimulating factor (GM-CSF).

GM-CSF, is crucial for the development of fully mature macrophage cells in the lungs, which are needed to clear away surfactant (a substance important to lung function), so that people can breathe.

In the study of PAP patients and mouse models of the disease, the researchers uncovered a more precise reason that disruption of cell regulation by GM-CSF triggers PAP.

It was because, cell dysregulation reduced the ability of macrophages to process and clear out cholesterol, allowing its levels to build up.

This contributed to the accumulation of surfactant that caused PAP and hindered breathing, according to study authors.

This improved respiratory function in the adult patients and in the laboratory models. Those tests were the result of earlier experiments on mouse pulmonary macrophages and cells donated from patients.



Source: IANS

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