About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Specially Engineered Skin Graft Boosts Healing in Burns

by Julia Samuel on October 29, 2016 at 9:52 AM
Font : A-A+

Specially Engineered Skin Graft Boosts Healing in Burns

Split thickness skin grafts (STSG) that use tissue from the patient may be a solution to treat burns.

Full thickness skin grafts are the golden standard for treating burn wounds. But most skin grafts for severe burns require a donor, and for large or complicated injury sites, a full thickness skin graft is hard to come by.

Advertisement


By combining STSG with a specially engineered sheet of stem cells, researchers from Michigan Tech and the First Affiliated Hospital of Sun Yat-sen University in Guangzhou, China demonstrate an improved skin graft process. Their work, published in Theranostics, focuses on creating engineered tissue that maximizes a body's natural healing power.

Feng Zhao, an associate professor of biomedical engineering at Michigan Tech, works on creating engineered tissues that are pre-vascularized and designed to get a jumpstart on growing veins, capillaries and lymphatic drainages. This is key when coupling the technology with STSG.
Advertisement

"STSG can be used under unfavorable conditions, such as a recipient's wound having moderate infection or less vasculature, where full thickness skin grafts would fail," Zhao says. "However, STSG are more fragile than full thickness skin grafts and can contract significantly during the healing process."

To help prevent graft contraction and encourage early vascularization to improve wound repair, Zhao and her team turned to stem cells, which her team modified to include pre-vascularized tissue.

The team's transplantation of combined graft-sheet in a rat model shows promising results. The implantations resulted in less contracted and puckered skin, less cellular inflammation, a thinner outer skin (epidermal) thickness along with more robust blood micro-circulation in the skin tissue. They also preserved features like hair follicles and oil glands.

The team attributes the success to the vascularized stem cell sheet's elevated levels of growth factors and proteins called cytokines used in healing tissue.

The greatest challenge is that both STSG and the stem cell sheets are fragile and difficult to harvest. Zhao says it will be crucial to improve the mechanical properties of the cell sheets and develop technology to more easily harvest them.

"The engineered stem cell sheet will overcome the limitation of current treatments for extensive and severe wounds, such as for acute burn injuries," Zhao says, "and significantly improve the quality of life for patients suffering from burns."

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Sugar Intake and Oral Health
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Boils / Skin Abscess Burns Pityriasis rosea Benefits of Meditation / Meditation Therapy Pemphigus Hives Scleroderma Vitiligo Skin Self Examination Dermatomyostitis 

Most Popular on Medindia

Calculate Ideal Weight for Infants Pregnancy Confirmation Calculator Hearing Loss Calculator Blood Pressure Calculator Sanatogen Sinopril (2mg) (Lacidipine) Daily Calorie Requirements Drug Interaction Checker Vent Forte (Theophylline) How to Reduce School Bag Weight - Simple Tips
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Specially Engineered Skin Graft Boosts Healing in Burns Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests