About Careers MedBlog Contact us

Simple Blood Test to Diagnose People With Active Tuberculosis

by Dr. Trupti Shirole on February 22, 2016 at 4:57 PM
Font : A-A+

Simple Blood Test to Diagnose People With Active Tuberculosis

Tuberculosis (TB) a disease that globally infects 9.6 million people each year and kills 1.5 million. A simple blood test that can accurately diagnose active TB has been developed by a team of US researchers, including an Indian-origin scientist.

Researchers at the Stanford University in California have found a gene expression that distinguishes patients with active TB from those with either latent TB or other diseases.


"The test can be used not only for diagnosis and to inform treatment, but also to study the effectiveness of different treatments. The test's hugely accurate negative response would be especially helpful in monitoring the effectiveness of treatments during clinical trials," said Purvesh Khatri, assistant professor at the university.

Named as the Khatri test, it works on an ordinary blood sample and removes the need to collect sputum - a common test for TB.

The results showed that the test could also signal a TB infection even if the individual also has human immunodeficiency virus (HIV).

The test won't give a positive response if someone only has latent TB or has had a TB vaccine. The test is 86% sensitive in children it works in adults too.

And if the test comes up negative, it's right 99% of the time. That is, of 100 patients who test negative with the Khatri test, 99 do not have active TB, the researchers elicited.

Further, the test can potentially be done under relatively basic field conditions in rural and undeveloped areas of the world.

"Any hospital should be able to perform the test. Villages without electricity could likely use ordinary blood samples and a solar-powered PCR machine, which multiplies strands of DNA, to accurately test people for active TB," Khatri mentioned.

Khatri's team identified three human genes whose expression changes in a consistent pattern, revealing the presence of an active tuberculosis infection.

The team validated the new three-gene test in a separate set of 1,400 human samples from 11 different data sets, confirming the diagnostic power of the test.

Source: IANS


Recommended Reading

Latest Research News

Learn How Brain Processes Your Daily Life
Studies using brain scans shows that how our brain helps us experience and remember our daily surroundings.
Fish's Sense may Help Restore Spinal Cord Injury Deficits
Scientists explore a potential mechanism that a jawless fish called the lampreys employs to swim again after spinal cord injuries.
Lesbian, Gay, And Bisexual (LGB) Preteens Unveil Higher Social Media Addiction
New study finds that lesbian, gay, and bisexual (LGB) preteens exhibit more social media and mobile phone addiction than straight peers.
Brain Region Linking Short-term to Long-term Memory Discovered
The model for memory consolidation claims that the hippocampus forms new memories and, as time goes on, trains the cortex to store enduring memories.
What Are the Effects of T Cells on Blood Pressure and Inflammation?
A new study explored the link between T immune cells in ill patients and mortality risk.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Simple Blood Test to Diagnose People With Active Tuberculosis Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests