About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Gender Influences on Nervous System Function

by Dr. Trupti Shirole on November 9, 2016 at 9:37 AM
Font : A-A+

Gender Influences on Nervous System Function

There are large differences in men and women that go well beyond their reproductive systems. Now, the Journal of Neuroscience Research is dedicating an issue entirely to sex differences at all levels of the brain, from the genetic and epigenetic level, to the synaptic, cellular, and systems levels.

In one study in the issue, researchers examined how variants in the gene that codes for a protein called galanin might influence susceptibility to multiple sclerosis (MS) in males compared with females. Recent studies have found elevated levels of this protein in post-mortem brain samples of patients with MS.

Advertisement


In this latest work, investigators compared the frequencies of "more active" and "less active" variants of the DNA sequences that control expression of the galanin gene between healthy controls and MS patients. Initially they found no difference between the two groups; however, when considering gender, there was a more than two fold decrease in a "less active" genetic variant in healthy men compared with healthy women.

Moreover, the presence of this variant increased susceptibility to MS in men but not in women. The presence of this variant in men was also associated with delayed onset of MS. Interestingly, the progression rate of MS was significantly accelerated in women if they carried the variant.
Advertisement

"We hope that our findings will foster development of a personalized strategy for the prevention and treatment of multiple sclerosis, one that takes into account the gender-specific contribution of galanin gene variants to susceptibility and disease progression," said Dr. Victoria Lioudyno, lead author of the study.

"Neuroscience today is at a crossroads. Do we continue the status quo and ignore sex as a biological variable, or do we acknowledge that sex influences the brain at all levels and address the major gaps in knowledge?" asked Dr. Eric M Prager, Editor-in-Chief of the Journal of Neuroscience Research.

"The work published in this issue unequivocally concludes that sex matters and that researchers can no longer allow for the over-reliance on male animals and cells, which obscure key differences that might influence clinical studies."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Aphasia Ataxia 

Most Popular on Medindia

The Essence of Yoga Nutam (400mg) (Piracetam) Vent Forte (Theophylline) Selfie Addiction Calculator Blood - Sugar Chart Diaphragmatic Hernia Accident and Trauma Care Drug Side Effects Calculator Post-Nasal Drip How to Reduce School Bag Weight - Simple Tips
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Gender Influences on Nervous System Function Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests