The Novo Nordisk Foundation Laureate Research Grant will provide $AUD 8.6 million over seven years for Professor Lars Nielsen, from UQ's Australian Institute for Bioengineering and Nanotechnology.
The grant is for the team to unravel the mystery around the detailed biology of cancer cells and develop complex computational models of cell metabolism.
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades.
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Professor Nielson together with a team of researchers at the Novo Nordisk Foundation Center for Biosustainability in Copenhagen will work to understand why cancer cells and other fast-growing cells produce lactate. This could lead to better and cheaper cancer therapies.
"This fellowship is granted to outstanding scientists undertaking groundbreaking biomedicine and biotechnology research, and is one of only two such competitive grants awarded worldwide each year", Professor Høj said.
![Acute Lymphoblastic Leukemia]( "Acute Lymphoblastic Leukemia")
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated.
Professor Nielsen hopes to build a detailed model of how cancer cells and other fast-growing cells produce lactic acid, an observation first made by German biochemist Otto Warburg in 1924.
"Ultimately we are trying to understand the molecular and metabolic differences between cancer cells and healthy cells. The same principles of protein expression and enzyme mechanism apply to non-growing cells, such as fat and liver cells, and our model may have even greater application to metabolic diseases, such as diabetes", Professor Nielsen said.
Professor Nielsen's work in modelling complex biological systems has been applied to systems as diverse as bacteria, baker's yeast, sugarcane and insects. Research partnerships with companies including Dow, Metabolix, Amyris, LanzaTech, Boeing, Virgin Australia and General Electric would be an additional support.
Source: Medindia
Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated.
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Professor Nielsen hopes to build a detailed model of how cancer cells and other fast-growing cells produce lactic acid, an observation first made by German biochemist Otto Warburg in 1924.
"Ultimately we are trying to understand the molecular and metabolic differences between cancer cells and healthy cells. The same principles of protein expression and enzyme mechanism apply to non-growing cells, such as fat and liver cells, and our model may have even greater application to metabolic diseases, such as diabetes", Professor Nielsen said.
Professor Nielsen's work in modelling complex biological systems has been applied to systems as diverse as bacteria, baker's yeast, sugarcane and insects. Research partnerships with companies including Dow, Metabolix, Amyris, LanzaTech, Boeing, Virgin Australia and General Electric would be an additional support.
Source: Medindia
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