About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Develop Functional Ovaries in Lab

by Sheela Philomena on March 27, 2013 at 12:19 PM
Font : A-A+

 Scientists Develop Functional Ovaries in Lab

Functional ovaries that showed sustained release of the sex hormones estrogen and progesterone have been developed by scientists.

The proof-of-concept study suggests the possibility of engineering artificial ovaries in the lab to provide a more natural option for hormone replacement therapy for women.

Advertisement

"A bioartificial ovary has the potential to secrete hormones in a natural way based on the body's needs, rather than the patient taking a specific dose of drugs each day," Emmanuel C. Opara, Ph.D., professor of regenerative medicine Wake Forest Baptist and senior researcher, said.

Tamer Yalcinkaya, M.D., associate professor and section head of reproductive medicine at Wake Forest Baptist, said "This research project is interesting because it offers hope to replace natural ovarian hormones in women with premature ovarian failure or in women going through menopause."
Advertisement

"The graft format would bring certain advantages: it would eliminate pharmacokinetic variations of hormones when administered as drugs and would also allow body's feedback mechanisms to control the release of ovarian hormones," he said.

It involves encapsulating ovarian cells inside a thin membrane that allows oxygen and nutrients to enter the capsule, but prevents patients from rejecting the cells, with this scenario, functional ovarian tissue from donors can be used to engineer bioartificial ovaries with non-functioning ovaries.

The team isolated the two types of endocrine cells found in ovaries (theca and granulosa) from 21-day-old rats and the cells were encapsulated inside materials compatible with body.

The function of the capsules was then evaluated in the lab by exposing them to follicle-stimulating hormone and luteinizing hormone, two hormones that stimulate ovaries to produce sex hormones.

The arrangement of cells that most closely mimicked the natural ovary (layers of cells in a 3-D shape) secreted levels of estrogen that were 10 times higher than other cell arrangements.

The capsules also secreted progesterone as well as inhibin and activin, two hormones that interact with the pituitary and hypothalamus and are important to the body's natural system to regulate the production of female sex hormones.

The research has been published in Biomaterials.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Is COVID-19 Vaccination during Pregnancy Safe?
Sensory Processing Disorder (SPD)
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Ovarian Cancer Oophorectomy 

Recommended Reading
Female Reproductive System - Animation
Interactive section of Medindia gives details regarding Female reproductive system showing how the ....
Women at High Risk of Ovarian Cancer Should Have Ovaries Removed
Women, who are at high risk of developing breast or ovarian cancer, should consider having their ......
Ovarian Cancer
Ovarian cancer affects both the ovaries and is referred to as the ''silent killer'' as the symptoms ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use