Medindia
Advertisement

Researchers Link Cholesterol Metabolism in Our Body With Anorexia

by Kathy Jones on September 13, 2013 at 10:29 PM
Font : A-A+

 Researchers Link Cholesterol Metabolism in Our Body With Anorexia

Gene coding variation for an enzyme responsible for the regulation of cholesterol metabolism in the body has been linked to eating disorder anorexia in a new study.

The study suggests that anorexia could be caused in part by a disruption in the normal processing of cholesterol, which may disrupt mood and eating behaviour.

Advertisement

For this project-the largest-ever sequencing study of anorexia - Nicholas J. Schork, a professor at The Scripps Research Institute (TSRI) worked with an international team of collaborators representing more than two dozen research institutions.

The project made use of genetic information from more than 1,200 anorexia patients and nearly 2,000 non-anorexic control subjects.

For an initial "discovery" study in 334 subjects, the researchers catalogued the variants of a large set of genes that had already been linked to feeding behavior or had been flagged in previous anorexia studies.
Advertisement

Of more than 150 candidate genes, only a handful showed statistical signs of a linkage with anorexia in this group of subjects.

"One of the strongest signs came from the gene EPHX2, which codes for epoxide hydrolase 2-an enzyme known to regulate cholesterol metabolism."

The team followed up with several replication studies, each using a different cohort of anorexia patients and controls, as well as different genetic analysis methods. The scientists continued to find evidence that certain variants of EPHX2 occur more frequently in people with anorexia.

Schork noted that people with anorexia often have remarkably high cholesterol levels in their blood, despite being severely malnourished.

The study has been published online in the journal Molecular Psychiatry.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cholesterol High Cholesterol Heart Attack Diet Lifestyle and Heart Disease Body Mass Index Cholesterol - The Enigma Chemical Liposuction Heart Attack- Lifestyle Risks Statins Healthy Living 

Recommended Reading
Anorexia Nervosa
Anorexia nervosa is an eating disorder most commonly found among teenage girls. Anorexia nervosa is ...
Orthorexia Nervosa
Are you a Health Food Junkie? Are you obsessed with what you eat all the time? You may be a victim ....
Indigestion
Indigestion or dyspepsia is referred to nonspecific symptoms or discomfort that causes persistent ....
Decreased Appetite Symptom Evaluation
A loss of appetite deprives an individual of essential nutrients and results in weight loss....
Body Mass Index
Body mass index (BMI) is a simple tool that is generally used to estimate the total amount of body f...
Cholesterol
Cholesterol is produced by the body (liver) and is essential for normal body functioning....
Cholesterol - The Enigma Chemical
The word 'Cholesterol' rings danger bells as soon as it is mentioned. This important chemical is im...
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the lead...
Heart Attack- Lifestyle risks
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoi...
High Cholesterol
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the w...
Liposuction
Liposuction is a cosmetic procedure, which is used to suck out the excess or abnormal fat deposition...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use