by VR Sreeraman on  April 2, 2011 at 6:58 PM Cancer News
 Researchers Identify New Therapeutic Target For Lung Cancer
Researchers at the Seoul National University have discovered a new therapeutic target for lung cancer.

It was found that a variant of the protein AIMP2 is highly expressed in lung cancer cells and also that patients demonstrating high expression of this variant showed lower survival.


AIMP2-DX2 compromises the tumor-suppressing activity of AIMP2 by competitively binding to p53.

It was also shown that suppression of AIMP2-DX2 slowed tumor growth, suggesting that this could be an exciting new therapeutic target.

The findings could create an opportunity to develop new innovative cancer drugs, as well as presenting a new target that could also be applied to other cancers.

The study has been published in the open-access journal PLoS Genetics.

Source: ANI

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