Researchers at the University of Copenhagen investigate the effect of antidepressant drugs to treat pain 'catastrophizing' in patients those underwent surgery. Pain catastrophizing is an irrational thought process that leads a patient to believe that the pain is more than it actually is.
Antidepressant drugs might reduce pain catastrophizing, but according to a study published in the official medical journal of the American Society of Anesthesiologists, that may not be the case, at least for acute pain.
Strong Evidence Shown for a New Class of Antidepressant Drugs
For the first time, scientists have shown that a chemical in the brain called galanin is involved in the risk of developing depression.
Advertisement
"Pain catastrophizing patients report more pain right after surgery, but whether or not targeted therapy can reduce pain among these patients had not been investigated," said Dr.Troels H. Lunn, MD, lead author, Department of Anaesthesiology and Intensive Care, University of Copenhagen, Denmark. "Our study was the first to investigate the effects of SSRIs (selective serotonin reuptake inhibitors, one class of antidepressants) on pain immediately after surgery."
Dr.Lunn and his colleagues studied 120 patients with pain catastrophizing disorder who were scheduled for total-knee replacement surgery. The patients were given either the escitalopram or a placebo daily from the day of surgery to the sixth day after surgery, in addition to a pain medication regime. Twenty-four hours after surgery, patients were asked to report their level of pain while walking. The researchers found that the antidepressant treatment did not reduce pain 24 hours after the procedure. They did, however, find that overall pain scores days two through six after surgery were reduced with the antidepressant treatment. According to Dr. Lunn, the findings suggest that initiating antidepressant treatment earlier may reduce pain immediately after surgery.
"This topic calls for future studies on the effect of this and other classes of antidepressants on postsurgical pain, and our study can serve as a basis for such research," said Dr. Lunn.
Source: Medindia
"This topic calls for future studies on the effect of this and other classes of antidepressants on postsurgical pain, and our study can serve as a basis for such research," said Dr. Lunn.
Source: Medindia
Downplaying Post-Operative Pain Can Actually Lessen Its Intensity in Patients
Playing down the level of pain that comes with a surgical procedure could actually make patients feel less pain, found a study.
Advertisement
 Patients Able To Talk With Their Physician About Depression With Help Of Interactive Computer ProgramPatients who used an interactive computer program about depression while waiting to see their primary-care doctor were nearly twice as likely to ask about the condition. | Advertisement
|
More Kids Use Antipsychotic, Antidepressant Drugs In Australia, Study Shows
More Aussie kids have begun using powerful antipsychotic, antidepressant medications, a study shows.
Advertisement
Recommended Readings
Latest Drug News
Examining FDA and patent records, researchers found that insulin manufacturers prolong market exclusivity for brand-name products.
The rise in FDA ODD awards indicates a collective endeavor to create new myelofibrosis medications devoid of mechanisms inducing anemia.
The most significant decrease in autoimmune thyroid disease risk was observed in rheumatoid arthritis patients receiving immunomodulatory drugs or 'biological DMARDs'.
Human apotransferrin injected to mice models suffering from intracerebral hemorrhage was found to mitigate the serious effects of stroke.
The reduction of these senescent osteoclasts, possibly through the utilization of current medications, could present a novel approach in managing lower back pain.