A new pathway activated by FLT3 mutation has been identified by scientists. Acute myeloid leukemia, a common leukemia in adults, is characterized by aberrant proliferation of cancerous bone marrow cells. Activating mutations in a protein receptor known as FLT3 receptor are among the most prevalent mutations observed in acute myeloid leukemias. Their results show that cyclin dependent kinase 1 (CDK1), a critical regulator of cell division is activated in FLT3 mutated leukemias, leading to the activation of downstream gene transcription. Most importantly, they demonstrate that inhibiting CDK1 activity promotes differentiation of cells from patient-derived peripheral blood samples. As clinical trials with CDK1 inhibitors are ongoing, their data strongly suggest that therapies targeting the CDK1 pathway may be efficacious for acute myeloid leukemias with FLT3 mutation, especially in patients resistant to FLT3 inhibitor therapies. Source: Eurekalert << New Method for Identifying Lung Nodules Identified Kate Upton Retaliates Against Pro-Anorexia Scoffs >> Recommended Reading Acute Myeloid Leukemia Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike READ MORE Leukemia / Blood Cancer Leukemia is cancer of blood-forming tissues in the body. READ MORE Leukemia-associated Risks Can Be Reduced Using Antibodies From Rabbit Demonstrations showed that the use of antibodies derived from rabbits can improve the survival and relapse outcomes of leukemia and myelodysplasia patients. READ MORE Assam To Offer Free Treatment For Children With Leukemia Assam children below the age of 12 years who suffer from leukemia are to get free treatment under the new scheme soon to be launched by the government. READ MORE Acute Lymphoblastic Leukemia Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated. READ MORE Bone Marrow Transplantation Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. READ MORE Chronic Myeloid Leukemia Chronic myeloid Leukemia is one of the most common types of blood cancer. It is characterized by excess of WBC stem cells in the bone marrow. READ MORE Leukemia Encyclopedia section of medindia gives general information about Leukemia READ MORE Multiple Myeloma Multiple Myeloma caught public attention when model turned actress Lisa Ray, who worked in Deepa Mehta’s ‘Water’ , declared that she had the incurable Multiple Myeloma. READ MORE Most Popular on Medindia Fongitar (Zinc Pyrithionone) Selfie Addiction Calculator Accident and Trauma Care More News on: LeukemiaChronic Myeloid LeukemiaAcute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMultiple MyelomaBone Marrow Transplantation
A new pathway activated by FLT3 mutation has been identified by scientists. Acute myeloid leukemia, a common leukemia in adults, is characterized by aberrant proliferation of cancerous bone marrow cells. Activating mutations in a protein receptor known as FLT3 receptor are among the most prevalent mutations observed in acute myeloid leukemias. Their results show that cyclin dependent kinase 1 (CDK1), a critical regulator of cell division is activated in FLT3 mutated leukemias, leading to the activation of downstream gene transcription. Most importantly, they demonstrate that inhibiting CDK1 activity promotes differentiation of cells from patient-derived peripheral blood samples. As clinical trials with CDK1 inhibitors are ongoing, their data strongly suggest that therapies targeting the CDK1 pathway may be efficacious for acute myeloid leukemias with FLT3 mutation, especially in patients resistant to FLT3 inhibitor therapies. Source: Eurekalert << New Method for Identifying Lung Nodules Identified Kate Upton Retaliates Against Pro-Anorexia Scoffs >> Recommended Reading Acute Myeloid Leukemia Acute myeloid Leukemia, more popularly known by its abbreviated form AML, is a fast- evolving leukemia that affects both children and adults alike READ MORE Leukemia / Blood Cancer Leukemia is cancer of blood-forming tissues in the body. READ MORE Leukemia-associated Risks Can Be Reduced Using Antibodies From Rabbit Demonstrations showed that the use of antibodies derived from rabbits can improve the survival and relapse outcomes of leukemia and myelodysplasia patients. READ MORE Assam To Offer Free Treatment For Children With Leukemia Assam children below the age of 12 years who suffer from leukemia are to get free treatment under the new scheme soon to be launched by the government. READ MORE Acute Lymphoblastic Leukemia Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated. READ MORE Bone Marrow Transplantation Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are injected into a recipient after treating them with growth factor. READ MORE Chronic Myeloid Leukemia Chronic myeloid Leukemia is one of the most common types of blood cancer. It is characterized by excess of WBC stem cells in the bone marrow. READ MORE Leukemia Encyclopedia section of medindia gives general information about Leukemia READ MORE Multiple Myeloma Multiple Myeloma caught public attention when model turned actress Lisa Ray, who worked in Deepa Mehta’s ‘Water’ , declared that she had the incurable Multiple Myeloma. READ MORE Most Popular on Medindia Fongitar (Zinc Pyrithionone) Selfie Addiction Calculator Accident and Trauma Care More News on: LeukemiaChronic Myeloid LeukemiaAcute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMultiple MyelomaBone Marrow Transplantation