About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Research: Oxygen Reduces the Heart's Ability to Regenerate

by Kathy Jones on April 25, 2014 at 8:39 PM
Font : A-A+

 Research: Oxygen Reduces the Heart's Ability to Regenerate

The newborn animal heart can heal itself completely, but the adult heart lacks this ability, according to previous research conducted at UT Southwestern Medical Center.

New research by the same team today has revealed why the heart loses its incredible regenerative capability in adulthood, and the answer is quite simple - oxygen.

Advertisement

Yes, oxygen. It is well-known that a major function of the heart is to circulate oxygen-rich blood throughout the body. But at the same time, oxygen is a highly reactive, nonmetallic element and oxidizing agent that readily forms toxic substances with many other compounds. This latter property has now been found to underlie the loss of regenerative capacity in the adult heart.

This groundbreaking new finding, published in today's issue of Cell, finds that the oxygen-rich postnatal environment results in cell cycle arrest of cardiomyocytes, or heart cells.
Advertisement

"Knowing the key mechanism that turns the heart's regenerative capacity off in newborns tells us how we might discover methods to reawaken that capacity in the adult mammalian heart," said Dr. Hesham Sadek, Assistant Professor of Internal Medicine at UT Southwestern and senior author of the study.

Due to the oxygen-rich atmosphere experienced immediately after birth, heart cells build up mitochondria - the powerhouse of the cell - which results in increased oxidization. The mass production of oxygen radicals by mitochondria damages DNA and, ultimately, causes cell cycle arrest.

"We have uncovered a previously unrecognized protective mechanism that mediates cardiomyocyte cell cycle arrest and that arises as a consequence of oxygen-dependent aerobic metabolism," said Dr. Sadek.

Physiologically speaking, Dr. Sadek said, mammals likely had to make the choice early on between being energy efficient or retaining the heart's ability to regenerate. "The choice was clear," said Dr. Sadek. "More than any organ in the body, the heart needs to be energy efficient in order to pump blood throughout life."

Heart muscle contains the highest amount of mitochondria in the body and consumes 30 percent of the body's total oxygen in a resting state alone. Unfortunately, the energy that comes from massive oxygen consumption comes with a price in the form of oxidation of DNA that makes the heart cells unable to divide and regenerate.

Dr. Sadek, along with co-first authors Dr. Bao "Robyn" Puente, postdoctoral trainee in Pediatrics, and Dr. Wataru Kimura, visiting senior researcher in Internal Medicine, found that if they subjected mice to a low-oxygen atmosphere, the cardiomyocytes divided longer than normal. The opposite was true when mice were born in a higher-oxygenated atmosphere. In that case, the cardiomyocytes stopped dividing earlier than normal.

This study comes on the heels of findings published in the Feb. 25, 2011, edition of Science, in which Dr. Sadek found that if a portion of a mouse heart was removed during the first week after birth, that portion grew back wholly and correctly. In contrast, an adult heart was irreversibly damaged by removal of even a small amount of tissue.

Because the adult mammal's heart is not able to regenerate following injury, this represents a major barrier in cardiovascular medicine. Having a promising new understanding of what arrests cardiomyocyte cell cycle could be an important component of cardiomyocyte proliferation-based therapeutic approaches.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Pericarditis 

Most Popular on Medindia

How to Reduce School Bag Weight - Simple Tips Sinopril (2mg) (Lacidipine) Color Blindness Calculator Diaphragmatic Hernia Iron Intake Calculator Vent Forte (Theophylline) Accident and Trauma Care Pregnancy Confirmation Calculator Daily Calorie Requirements Selfie Addiction Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Research: Oxygen Reduces the Heart's Ability to Regenerate Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests