Relief for Xerostomia in Cancer Patients on the Anvil

by Kathy Jones on  July 17, 2010 at 10:07 PM Cancer News
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Presenting author S. Pradhani, University of Delaware, Newark, USA, will present an abstract titled "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels" at the 88th General Session & Exhibition of the International Association for Dental Research, in Barcelona, Spain.
 Relief for Xerostomia in Cancer Patients on the Anvil
Relief for Xerostomia in Cancer Patients on the Anvil

The goal of this research was to create an ECM modified hyaluronic acid (HA) based hydrogel culture system that allows for the growth and differentiation of salivary acinar cells into functional acini-like structures capable of secreting large amounts of protein and fluid unidirectionally. Xerostomia, a condition resulting from irradiation of the head and neck, affects more than 40,000 cancer patients each year in the United States. According to this research, these patients will greatly benefit from the development of a functional implantable artificial salivary gland.

In this study, an IRB approved protocol was established and salivary gland tissue was obtained from patients undergoing head and neck surgery. Tissue specimen was dissociated to obtain acinar enriched cultures. Biomarker studies with the salivary enzyme, α-amylase and tight junction proteins such as zonula occludens-1 and E-cadherin, confirmed the phenotype of these cells. Acinar cells were seeded on HA-based hydrogels to obtain lobular structures with central apoptosing cells and lumen.

An HA-based hydrogel system was developed to aid the differentiation of acinar cells into lobular acini-like structures. Functionality of these structures was demonstrated by the use of neurotransmitters that enhance their fluid and protein secretion pathways. Future experiments will involve implantation of these hydrogels in animal models to test their functionality in vivo.

This is a summary of abstract #539, "Salivary Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels," to be presented by S. Pradhani at 11:45 a.m., Thursday, July 15, 2010 in Room 133 of the Centre Convencions Internacional Barcelona, Spain during the 88th General Session & Exhibition of the International Association for Dental Research.

Source: Eurekalert

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I developed Severe dry mouth after my radiation was completed, I tried pretty much ALL the known products out there, and NONE of them worked. I searched online and found AQUORAL ARTIFICIAL SALIVA from a U.S Company called Bi-Coastal Pharm Corp. they have a website at Well after getting my doctor to write a script for me, and after using this product for a day and a half i started to see immediate releif. Best part is, there are no side effects, tastes like a citrus flavor, and comes in a little pump spray bottle that is a month's supply. This stuff really works and helped me. I called the company and they told me they re-launched this product about a year ago and are trying to make more people aware of it. You can get it from any Doctor as the company said it is distributed nationally, jstu have to make your Doc search for it in there systems as they may not have heard of it.


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