About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Potential Chemotherapeutic Drug to Treat Hepatocellular Carcinoma on the Anvil

by Kathy Jones on August 1, 2010 at 3:29 PM
Font : A-A+

 Potential Chemotherapeutic Drug to Treat Hepatocellular Carcinoma on the Anvil

It is well-known that hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, particularly in China, but HCC remains one of the more difficult cancers to treat. It is important to screen for new anti-cancer drugs.

A number of dietary compounds possess anti-cancer properties. These dietary compounds may modify the activity of specific targets that control cell proliferation and apoptosis. Galangin could inhibit the methoxyresorufin O-demethylase activity of CYP1A2, CYP1A1 and P-form phenolsulfotransferase. Galangin induced apoptosis in several cancer cell lines and arrested the cell cycle, modulated the expression of cycline/cdk, and decreased Bcl-2. It was suggested that galangin may be a potential anti-tumor agent. However, the mechanism by which galangin exerts its anti-tumor activity is unknown.

Advertisement

A research article to be published on July 21, 2010 in the World Journal of Gastroenterology addresses this question. This is the first study to report that galangin mediates apoptosis through a mitochondrial pathway.

Their data demonstrated that (1) galangin induces HCC cell apoptosis by triggering Bax translocation to the mitochondria; (2) galangin-treated HCC cells causes the release of AIF and cytochrome c into the cytosol from the mitochondria; and (3) overexpression of Bcl-2 attenuated galangin-induced HepG2 cells apoptosis, while down-regulated Bcl-2 expression enhanced galangin to induce cell apoptosis.

Understanding the mechanism by which galangin induces apoptosis may lead to its use as an anti-cancer treatment of HCC. This study may represent a future potential chemotherapeutic drug in the treatment of HCC with galangin.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Signature Drug Toxicity Liver Breast Cancer Radiofrequency Ablation for Liver Cancer Tumors Hepatectomy Hepatomegaly 

Most Popular on Medindia

Daily Calorie Requirements Loram (2 mg) (Lorazepam) Post-Nasal Drip Find a Hospital Turmeric Powder - Health Benefits, Uses & Side Effects Drug - Food Interactions Sanatogen Noscaphene (Noscapine) Color Blindness Calculator Drug Side Effects Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Potential Chemotherapeutic Drug to Treat Hepatocellular Carcinoma on the Anvil Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests