About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

PEth Test Can Identify Alcohol Misuse in Critically Ill Patients

by Hannah Joy on November 10, 2017 at 7:40 PM
Font : A-A+

PEth Test Can Identify Alcohol Misuse in Critically Ill Patients

PEth, a simple blood test helps in identifying alcohol misuse in critically ill hospital patients, reveals a new study.

The finding is important because patients who misuse alcohol tend to have worse outcomes. If validated in further studies, the PEth test could help doctors anticipate and perhaps ward off alcohol-related complications such as organ failure and impaired healing of wounds and bones.

Advertisement


The study, published in Alcoholism: Clinical & Experimental Research, included researchers from Loyola University Chicago Stritch School of Medicine, Loyola University Medical Center and the University of Colorado and was led by Loyola Medicine pulmonologist Majid Afshar, MD.

Patients who misuse alcohol and subsequently arrive at the hospital in critical condition develop more complications, have longer recovery times, develop organ dysfunction more frequently and are at greater risk of dying, according to earlier studies by Dr. Afshar and other researchers.
Advertisement

Alcohol misuse is defined as heavy drinking (one or more drinks per day for women and two or more drinks per day for men) and/or binge drinking (four or more drinks per occasion for women and five or more drinks for men).

Current methods to identify alcohol misuse are problematic. For example, many critically ill patients in intensive care lack the capacity to answer questions about alcohol use. And testing blood alcohol concentration does not distinguish among different types of alcohol use, such as heavy daily use or occasional binge drinking.

An alternative test measures phosphatidylethanol (PEth), a compound in the blood that is a biomarker of alcohol use. With a half-life of four to 12 days, PEth lasts much longer in the body than blood alcohol concentration. (Half-life is the time it takes for PEth to fall to half its original level.) PEth remains detectable for up to three weeks.

The study enrolled 122 adults at Loyola University Medical Center and the University of Colorado Denver: 33 were critically ill patients treated in intensive care and burn units; 51 were treated in an alcohol detoxification unit; and 38 served as healthy controls.

Alcohol misuse was determined by giving participants the Alcohol Use Disorders Identification Test, which asks questions such as how often a participant binge drinks, is unable to stop drinking or feels remorseful about drinking.

The study found that a PEth level of at least 250 nanograms per milliliter (ng/ml) was 88.7 percent accurate in identifying participants who display alcohol misuse and a level higher than 400 ng/ml was 83 percent accurate in identifying those who showed severe alcohol misuse.

The study is the first to examine the role PEth could play in critically ill patients. The findings "demonstrate good diagnostic accuracy for PEth in discriminating alcohol misuse, with useful cut-points to risk-stratify patients," Dr. Afshar and colleagues concluded.

"Further validation in a more representative sample of critically ill patients is needed prior to clinical and research application."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alcoholic Liver Disease Alcoholism Cannabis Drug Abuse Undescended Testicles Alcohol and Driving Bubbles and Brews - Alcohol Facts Varicocele Pancreatitis Alcohol Addiction and Women 

Recommended Reading
Long-term Exposure to Alcohol Kills Stem Cells in the Brain
Alcohol has negative effects on the stem cells in the brain, especially in females, shows study....
Alcohol Abuse in Family Linked With Teenage Dating Violence
Teenagers who had fathers with an alcohol use disorder were found to be involved in abusive dating ....
YouTube Videos Promoting 'Fun' Side of Alcohol on the Rise
Although classified as a depressant, the amount of alcohol consumed determines the type of effect. ....
Alcohol Alters Expression of Genes That Regulate Cholesterol
Regulation of the PCSK9 gene is found to be the factor behind cholesterol levels and cardiovascular ...
Alcohol Addiction and Women
Social drinking amongst women has become a fad. Stop it before it finishes you....
Alcohol and Driving
Alcohol and driving do not mix. Drunken driving is the cause of many deaths in the world....
Alcoholic Liver Disease
Encyclopedia section of medindia gives general information about Alcoholic Liver Disease....
Alcoholism
Alcohol use disorder or alcoholism is an inability to control drinking. It can cause short term and ...
Bubbles and Brews - Alcohol Facts
There is more to alcohol than mere intoxication. Infamous because of its social abuse but indispensa...
Cannabis
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or sub...
Pancreatitis
Pancreatitis or inflammation of the pancreas may show up as acute pancreatitis or chronic pain. Alco...
Undescended Testicles
An undescended testicle / testis is one that has not descended into the scrotal sac before birth. It...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use