In mice, influenza vaccine delivered via microneedle patch provided 100 percent protection against a lethal influenza virus. They report their findings in the September 2013 issue of the journal Clinical and Vaccine Immunology.
Microneedles are a medium for delivery of influenza vaccine that avoids the pain associated with ordinary hypodermic needles. They are a mere seven tenths of a millimeter in length, and the volume of vaccine—a major contributor to pain—is minuscule.
Bird Flu
Bird flu (avian influenza/avian flu) is a disease caused by an influenza virus (H5N1) that primarily affects birds but can infect humans also.
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Instead of a liquid containing whole killed or attenuated virus, this vaccine uses dry virus-like particles (VLPs) which simply coat the needles in the presence of a simple stabilizing agent, reducing the need for refrigeration — a potential boon for use in developing countries. The lower dose required when using microneedles also reduces the potential for side effects, such as lung inflammation.
"This method can induce higher levels of IgG2a antibodies as well as rapid recall immune responses following lethal challenge infection. Our previous study showed that microneedle vaccination induced higher levels of antibody-secreting cells in spleen and bone marrow compared to intramuscular vaccination," says Sang-Moo Kang of Georgia State University, a researcher on the study.
![Influenza Vaccines Promotion Gears Up]( "Influenza Vaccines Promotion Gears Up")
One of the most aggressive public health policies today is the promotion of influenza vaccines
Earlier studies by this group showed that influenza VLP-coated microneedles actually produced higher short-term protection than conventional intramuscular immunization. In this study the researchers tested how effective the long-term protection of the vaccine was. Mice that received the vaccine were 100 percent protected from a lethal challenge with the influenza virus 14 months after vaccination.
Kang says his aim was to develop an easier and pain-free method of vaccine delivery. He also says that patients could probably use this system to vaccinate themselves.
Source: Eurekalert
Influenza Vaccines Promotion Gears Up
One of the most aggressive public health policies today is the promotion of influenza vaccines
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Earlier studies by this group showed that influenza VLP-coated microneedles actually produced higher short-term protection than conventional intramuscular immunization. In this study the researchers tested how effective the long-term protection of the vaccine was. Mice that received the vaccine were 100 percent protected from a lethal challenge with the influenza virus 14 months after vaccination.
Kang says his aim was to develop an easier and pain-free method of vaccine delivery. He also says that patients could probably use this system to vaccinate themselves.
Source: Eurekalert
Peptides That Could Lead to Universal Influenza Vaccine Identified
Researchers have discovered a series of peptides found on the intestinal structures of influenza viruses that could pave way for the development of a universal vaccine for influenza.
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 Important Properties of Influenza Vaccines Now RevealedAn important mechanism for stimulating the protective immune response following seasonal flu vaccinations, is now clearly identified by scientists. | Advertisement
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