The 3D organoid models derived from patient cells aid in developing personalized therapy for each and every individual suffering with gastrointestinal cancer.
Organoids are artificially grown masses of cells or tissues that resemble organs that are being used by researchers in a range of biomedical fields as they study various disease states and work to develop potential treatments.
Organoid culture methods have been established for healthy and diseased tissues from oesophagus, stomach, intestine, pancreas, bile duct, and liver.
"Research using organoids has already unraveled so many of the underlying causes of cancer. But, for me, their real promise lies in their capacity to predict treatment response," said lead author Merel Aberle, MD, of Maastricht University, in The Netherlands.
"In future, organoids could be used to find the best treatment combination for every patient, thereby increasing response rates, but also reducing the side-effects unnecessary treatment may cause. I hope that this review inspires more surgeons, oncologists, radiologists, and other healthcare professionals to use this model and set up collaborative clinical trials."
The new study was published in British Journal of Surgery (BJS).