"We showed that fat tissue controls brain function in a really interesting way," said senior author Shin-ichiro Imai, professor of developmental biology and of medicine at the Washington University School of Medicine in St. Louis.
The researchers found that in mice the enzyme called NAMPT, secreted by fat tissues, affects the hypothalamus, a part of the brain known to have important roles in maintaining the body's physiology, including regulating body temperature, sleep cycles, heart rate, blood pressure, thirst and appetite.
The findings may help explain the many studies that show a survival benefit to having a body mass index toward the low end of what is considered overweight. For the current study, the researchers raised mice that lacked the ability to produce NAMPT only in the fat tissue.
Mice with low NAMPT in fat tissue had low fuel levels in the hypothalamus. These mice also showed lower measures of physical activity than mice without this defect. Mice that expressed high levels of NAMPT in the fat tissue were very physically active.
The study appeared in the journal Cell Metabolism.
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