Legumain (LGMN) may serve as both a potential oncogenic marker and a
molecular target for treatment of cancer especially for personalized
medicine. Although recent findings have shed light on the functional
roles and expression patterns of LGMN, further investigations are still
warranted to elucidate the exact role and underlying mechanism of action
for LGMN in cancer.
LGMN, or asparaginyl endopeptidase, is a newly identified
lysosomal cysteine protease. It was recently found to be over-expressed
in tumor microenvironment , an enclosed environment that facilitates
the interaction among the human solid tumors, tumor-associated
endothelial and stromal cells, as well as in tumor-associated
macrophages.
Dietary Phenols Could Play a Role in Cancer Treatment
Plant phenols obtained from the diet could play a role in the prevention and treatment of cancers.
Advertisement
‘Targeting legumain (LGMN) directly or utilizing LGMN as a prodrug activator are promising strategies for cancer management in the future.’
Tweet it Now
These non-malignant cells support the growth of the tumors, metastasis and the survival of tumors. One of the identified key biomarkers driving the complexity of tumor microenvironment is LGMN. LGMN is a robust acidic cysteine endopeptidase with remarkably restricted specificity for hydrolysis of asparaginyl bonds.
LGMN is well conserved, having been reportedly present in plants,
invertebrate parasites, as well as in mammals. Mammalian LGMN processes
the self and foreign antigens expressed by antigen presenting cells and
proteolytically activates toll-like receptor, the innate immunity
receptor.
![Over-the-counter Heartburn Meds Could Worsen Cancer Treatment]( "Over-the-counter Heartburn Meds Could Worsen Cancer Treatment")
Medications for heartburn and gastric issues could lower possibility of survival and recovery for cancer patients.
Since LGMN has been implicated in tumor development and can potentially be developed into both diagnostic and therapeutic markers. This review aims to relate the recent findings on the biology of LGMN in cancers, to the therapeutic advancements in targeting LGMN in human cancers.
Recent discoveries have also demonstrated that targeting LGMN directly or utilizing LGMN as a prodrug activator are promising strategies for cancer management in the future. However, further research is necessary before such therapeutic strategies can be fully realized.
Source: Eurekalert
Over-the-counter Heartburn Meds Could Worsen Cancer Treatment
Medications for heartburn and gastric issues could lower possibility of survival and recovery for cancer patients.
Advertisement
Since LGMN has been implicated in tumor development and can potentially be developed into both diagnostic and therapeutic markers. This review aims to relate the recent findings on the biology of LGMN in cancers, to the therapeutic advancements in targeting LGMN in human cancers.
Recent discoveries have also demonstrated that targeting LGMN directly or utilizing LGMN as a prodrug activator are promising strategies for cancer management in the future. However, further research is necessary before such therapeutic strategies can be fully realized.
Source: Eurekalert
Novel Implant Identifies Suitable Drug for Individualized Cancer Treatment
The implant shows activity of each drug on the tumor and indicates drugs that will work best on the cancer as a whole.
Advertisement
 Patient Navigation may Lead to Better Breast Cancer Treatment in High-Risk WomenThe linking of a newly diagnosed cancer patient with a professional trained in assisting patients though the complex journey of cancer diagnosis and treatment, may lead to better breast cancer care in high risk and minority women. | Advertisement
|
Advertisement
