A biocompatible scaffold capable of
controlled-release of silver ions that inhibits infection of bone by methicillin-resistant Staphylococcus
aureus (MRSA) has been developed by researchers.
The antimicrobial properties of silver combined with a biodegradable scaffold that can be seeded with bone-forming stem cells offers a potential implant system for treating and preventing bone infection, as described in an article published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
Mahsa Mohiti-Asli and coauthors from University of North Carolina at Chapel Hill, North Carolina State University (Raleigh), Silpakorn University (Nakornpathom, Thailand), and University of Missouri (Columbia), present an experiment in which they seeded bone-forming stem cells on three-dimensional scaffolds either with or without MRSA.
"Hybrid therapeutic approaches such as this combination of a regenerative and anti-infective platform are transforming our attack on complex musculoskeletal diseases," says Co-Editor-in-Chief Peter C. Johnson, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.
Research reported in this publication was supported by the Clinical and Translational Science Awards (CTSA) program of the National Institutes of Health under grant numbers 550KR71418 and 550KR61325, and the National Institute of Biomedical Imaging and Bioengineering under grant number 1R03EB008790. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.