A biocompatible scaffold capable of
controlled-release of silver ions that inhibits infection of bone by methicillin-resistant Staphylococcus
aureus (MRSA) has been developed by researchers.
The antimicrobial properties of silver combined
with a biodegradable scaffold that can be seeded with bone-forming stem
cells offers a potential implant system for treating and preventing bone
infection, as described in an article published in Tissue Engineering
, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
‘The antimicrobial properties of silver combined with a biodegradable scaffold can be seeded with bone-forming stem cells to offer a potential implant system for treating and preventing bone infection.’
Mahsa Mohiti-Asli and coauthors from University of North
Carolina at Chapel Hill, North Carolina State University (Raleigh),
Silpakorn University (Nakornpathom, Thailand), and University of
Missouri (Columbia), present an experiment in which they seeded
bone-forming stem cells on three-dimensional scaffolds either with or
The researchers assessed bacterial biofilm formation to
determine the effect of silver ions on bone infection (osteomyelitis).
They report their findings in the article entitled "Evaluation
of Silver Ion-Releasing Scaffolds in a 3D Coculture System of MRSA and
Human Adipose-Derived Stem Cells for Their Potential Use in Treatment or
Prevention of Osteomyelitis."
"Hybrid therapeutic approaches such as this combination of a
regenerative and anti-infective platform are transforming our attack on
complex musculoskeletal diseases," says Co-Editor-in-Chief Peter C.
Johnson, Principal, MedSurgPI, LLC and President and CEO,
Scintellix, LLC, Raleigh, NC.
Research reported in this publication was supported by the Clinical
and Translational Science Awards (CTSA) program of the National
Institutes of Health under grant numbers 550KR71418 and 550KR61325, and
the National Institute of Biomedical Imaging and Bioengineering under
grant number 1R03EB008790. The content is solely the responsibility of
the authors and does not necessarily represent the official views of the
National Institutes of Health.