Novel 3D Flexible Neural Interface for Brain Activity and Drug Delivery

Neuronal activity can be measured using a newly designed brain chip implant – while simultaneously delivering drugs to the implant site.

Neuronal activity can be measured using a newly designed brain chip implant while simultaneously delivering drugs to the implant site as developed by researchers at the DGIST (Daegu Gyeongbuk Institute Of Science And Technology).

The study “A 3D flexible neural interface based on a microfluidic interconnection cable capable of chemical delivery” was published in the journal Microsystems & Nanoengineering.

Understanding the Neuronal Activity-Dependent Gene Expression by CREB
Neuronal activity mediates the formation of neuronal circuits in the cerebral cortex. These processes are regulated by the transcription factor CREB.

‘Neuronal activity can be measured using a newly designed brain chip implant – while simultaneously delivering drugs to the implant site. ’

The developments in the field of the electrical activity of the brain have allowed greater insights into the brain’s processes, functions, and diseases over the past decades. The most commonly used method is electroencephalography (EEG).

“The flexibility and functionalities of our device will help make it more compatible with biological tissues and decrease adverse effects, all of which contribute to increasing the lifespan of the neural interface,” says Prof. Sohee Kim from Daegu Gyeongbuk Institute of Science and Technology (DGIST), Korea, who led the study.

3D flexible neural interface

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Stressful life events such as job loss, accident, death of a loved one can trigger major depression in one person, but not in another.

Earlier studies on the development of long-lasting brain interfaces remain challenging. However, the new study has designed a 3D multifunctional and flexible neural interface that can be implanted directly into the brain. Moreover, it can also deliver liquid drugs to the implantation site.

The study results were validated through brain interface experiments on live rats, followed by an analysis of the drug concentration in the tissue around the needles. Hence, the device holds several implications across multiple disciplines.

Neuronal Activity of the Brain Studied by Novel Biomarker
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“Our device may be suitable for brain–machine interfaces, which enable paralyzed people to move robotic arms or legs using their thoughts, and for treating neurological diseases using electrical and/or chemical stimulation over years,” says Dr. Yoo Na Kang of the Korea Institute of Machinery & Materials (KIMM), first author of the study.

Source-Medindia

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