Routine use of Gabapentin, a non-opioid pain medication, after surgery reduces dependence on opioid medication for pain relief.
Gabapentin Co-use With Opioid Results in Fatal Side Effects
New Study suggests that co-prescription of gabapentin with opioid painkillers increases risk of fatal opioid overdose and breathing suppression.
New Study suggests that co-prescription of gabapentin with opioid painkillers increases risk of fatal opioid overdose and breathing suppression.
‘Routine use of gabapentin before and after surgery may be warranted if it can promote opioid cessation and prevent chronic use of opioids.’
Patients scheduled for surgery from May 2010 to July 2014 and followed up to two years Gabapentin before and after surgery or the active placebo lorazepam before surgery and an inactive placebo after surgery (interventions); time to pain resolution (five consecutive reports of zero on a pain scale) and time to opioid cessation (five consecutive reports of no opioid use) (outcomes); 410 patients were separated nearly evenly into gabapentin or placebo treatment groups
This was a randomized clinical trial (RCT). An RCT allows for the strongest inferences to be made about the true effect of an intervention. However, not all RCT results can be replicated in real-world settings because patient characteristics or other variables may differ from those that were studied in the RCT.
Gabapentinoids Not Effective For Chronic Low Back Pain
Existing evidence on the use of gabapentinoids for CLBP showed no significant improvements in pain and reported adverse events like dizziness, fatigue, confusion, and visual changes
Existing evidence on the use of gabapentinoids for CLBP showed no significant improvements in pain and reported adverse events like dizziness, fatigue, confusion, and visual changes
• Patients who received gabapentin had a modest increase in opioid cessation.
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Empty capsules found, Aurobindo Pharma recalls Gabapentin
After finding out that one lot of Gabapentin Capsules 300 mg had empty capsules, Aurobindo Pharma, US, has recalled the lot.
After finding out that one lot of Gabapentin Capsules 300 mg had empty capsules, Aurobindo Pharma, US, has recalled the lot.
Study Conclusions: Routine use of gabapentin before and after surgery may be warranted if it can promote opioid cessation and prevent chronic use of opioids.
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Gabapentin Inhibits Central Sensitization During Migraine, Say Researchers
Excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine, find researchers.
Excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine, find researchers.
Source-Eurekalert
