About Careers MedBlog Contact us

Non-adherence to Treatment Regime Linked to Adverse Clinical Outcomes in Liver Transplant Recipients

by Dr. Trupti Shirole on December 12, 2014 at 6:18 AM
Font : A-A+

 Non-adherence to Treatment Regime Linked to Adverse Clinical Outcomes in Liver Transplant Recipients

New research reports that liver transplant recipients' less understanding of treatment regime and non-adherence to medications is linked to adverse clinical outcomes, such as organ rejection or graft loss. Immunosuppressive drug therapies help improve survival rates for those undergoing solid organ transplantation. However, their effectiveness may be hindered by multidrug regimens that require strict adherence overtime, with non-adherence responsible for close to 50% of late acute rejections and 15% of graft losses in adults.

The research team enrolled 105 liver transplant patients, majority of which were middle-aged men. 15% of the group had limited literacy. The average number of medications used by patients was 11, with 39% of the group having had a change in medication within the last month. Results showed that on an average 86% patients understood their entire medication regimen, with 78% adhering to the therapy regime. Self-reported non-adherence to the treatment regimen was 14% and based on tacrolimus levels the number more than doubles to 32% of patients.  


Low income, lesser time since transplant, higher number of medications and limited literacy were associated with lower treatment knowledge scores, and more medications and limited literacy were linked to non-adherence to the treatment regimen by tacrolimus levels.

Dr. Marina Serper with the Hospital of the University of Pennsylvania in Philadelphia said, "By involving existing transplant center resources in cost-effective interventions that help patients properly manage their drug regimens, we could see an improvement in long term health of solid organ transplant recipients."

The study is published in Liver Transplantation, a journal of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Source: Medindia


Recommended Reading

Latest Research News

Omega-3 Can Save Alzheimer's Patients from Vision Loss
Does omega-3 help Alzheimer's patients? A new form of omega-3 helped restore specific markers of eye health in mice bred with aspects of early-onset Alzheimer's disease.
Why Is Asthma Linked to Increased Risk of Osteoarthritis?
Drugs used to inhibit the physiological responses for allergic reactions lessen osteoarthritis risk, revealed research.
 Experiments on Child Brain Tumour and Muscle Ageing Heading to Space
The International Space Station will be used to carry out experiments seeking to improve understanding of incurable child brain tumors and the muscle aging process.
 Nearly 1 In 5 UK Adults Experience Negative Responses to Sounds
How many people in the UK have misophonia? In a representative sample study, most people had at least some irritation upon hearing trigger sounds.
Why Are 1 in 8 Indians at Risk of Irreversible Blindness
Routine eye-checkups and mass screenings enable early diagnosis and treatment of glaucoma. Late-stage glaucoma diagnosis leads to blindness.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Non-adherence to Treatment Regime Linked to Adverse Clinical Outcomes in Liver Transplant Recipients Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests