About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Ways to Impede Progress of Neurodegenerative Diseases Discovered

by Colleen Fleiss on April 3, 2018 at 1:19 AM
Font : A-A+

New Ways to Impede Progress of Neurodegenerative Diseases Discovered

A new paper in Bioorganic & Medicinal Chemistry Letters talks about the mechanism of influence of methanofullerenoles on hyperpolarized mitochondria. Kazan University's partner in this research is the Arbuzov Institute of Organic and Physical Chemistry.

The joint team proved that water-soluble polyol-methanofullerenes C60[C9H10O4(OH)4]6 and C60[C13H18O4(OH)4]6 can decrease mitochondrial transmembrane potential. This makes them promising in the creation of targeted mitochondrial medications and composites based on them.

Advertisement


Hyperpolarized mitochondria have an elevated transmembrane potential because of the excess of H+ ions in the intermembrane space in comparison with the matrix (pH 8). Protonophores decrease the mitochondrial potential by facilitating electrogenic transport of protons through inner mitochondrial membrane. The most useful of them are soft protonophores which only remove the excess of the potential but don't decrease it below the necessary limit.

Natalia Kalacheva et al. state that the researched methanofullerenoles can accept protons in acidic medium characteristic for intermembrane space of hyperpolarized mitochondria. Protonated molecules transfer protons into the mitochondrial matrix. As a consequence, the proton gradient is dissipated, which causes a decrease in mitochondrial transmembrane potential and reduction in ROS production.
Advertisement

In the publication, the authors describe water-soluble polyol-methanofullerenes as soft protonophores because they can accept H+ ions only in hyperpolarized mitochondria and cannot penetrate normally polarized mitochondria. The research was based at the KFU Gene and Cell Technologies Lab and funded by Project 5-100.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Black Tea Protects against Blood Pressure and Heart Diseases
Green Mediterranean Diet may Help Repair Age-Related Brain Damages
Cervical Cancer Awareness Month 2022
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Spinocerebellar Ataxia 

Recommended Reading
Healthy Mitochondria May Stop Alzheimer’s Disease
Enhancing mitochondrial proteostasis reduces the formation of amyloid plaques and delays ......
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Quiz on Cancer
Cancer, is the second most leading cause of death worldwide. Cancer is not just one disease but ......
Autoimmune Disorders
Autoimmune disorders occur when the immune system fails to recognize the body as 'self' and attacks ...
Spinocerebellar Ataxia
Spinocerebellar ataxia (SCA) is a progressive, neurodegenerative, genetic disease, which has no cur...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)