Use of acid-suppressive medications and antibiotics in the first 6 months of infancy was associated with the subsequent development of allergic diseases, including asthma, in childhood, stated study.
Allergic diseases and asthma have been on the rise over several decades. Medications that can alter the human microbiome may contribute to the rise of allergic diseases. Acid-suppressing medicines and antibiotics can contribute to a microbial imbalance in the gut (intestinal dysbiosis).
792,130 children born between October 2001 and September 2013 and enrolled in the military health system until at least age 1 Any dispensed prescription for a histamine-2 receptor antagonist (H2RA), proton pump inhibitor (PPI) or antibiotic (exposures) in the first six months of life; allergic disease defined as the presence of food allergy, anaphylaxis, asthma, atopic dermatitis (eczema), allergic rhinitis (hay fever). allergic conjunctivitis (eye inflammation), urticaria (rash), contact dermatitis (skin rash), medication allergy or other allergy (outcomes)
The use of acid-suppressing medicines was associated with increased risks for all major categories of allergic disease, especially food allergy. Antibiotics also were associated with increased risk of all major categories for allergic disease. It is possible that acid-suppressing medicines or antibiotics were given for allergic diseases that were misdiagnosed, although the authors doubt this can explain all their findings. The mechanisms by which acid-suppressing medicines and antibiotics might increase allergic sensitization also are not fully understood but potential ones could include intestinal dysbiosis and, for acid-suppressing medicines, decreased protein digestion in the stomach.
An editor article review podcast with Aaron E. Carroll, M.D., M.S., JAMA Pediatrics digital media editor, also is available on the For The Media website. The audio transcript is available here.