About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Technique Unveils Brain Abnormalities That May Play Key Role In ADHD

by VR Sreeraman on November 19, 2008 at 4:08 PM
Font : A-A+

 New Technique Unveils Brain Abnormalities That May Play Key Role In ADHD

Using a new analysis tool, scientists - for the first time - have revealed shape differences in the brains of kids Attention-Deficit Hyperactivity Disorder (ADHD), which could help pinpoint the specific neural circuits involved in the disorder.

The new tool, called large deformation diffeomorphic mapping (LDDMM), allowed researchers at the Kennedy Krieger Institute in Baltimore, Md. and the Johns Hopkins Center for Imaging Science to examine the precise shape of the basal ganglia.

Advertisement

In the study, the researchers found that boys with ADHD had significant shape differences and decreases in overall volume of the basal ganglia compared to their typically developing peers.

Girls with ADHD did not have volume or shape differences, suggesting sex strongly influences the disorder's expression.

LDDMM provides detailed analysis of the shape of specific brain regions, allowing for precise examination of brain structures well beyond what has been examined in previous MRI studies of ADHD.
Advertisement

In this study, LDDMM was used to map the brains of typically developing children in order to generate a basal ganglia template.

After creating LDDMM mappings of the basal ganglia of each child with ADHD, statistical analysis was conducted to compare them to the template.

In this study, the initial volume analysis revealed boys with ADHD had significantly smaller basal ganglia volumes compared with typically developing boys.

Moving beyond the standard volume analysis, the LDDMM revealed shape abnormalities in several regions of the basal ganglia. Comparison of the standard volume and LDDMM analysis of girls with ADHD and their typically developing peers failed to reveal any significant volume or shape differences.

The multiple shape differences found in boys with ADHD suggest that the disorder may not be associated with abnormalities in one specific neural circuit.

In fact, it seems that the disorder involves abnormalities in parallel circuits, including circuits important for the control of complex behaviour and more basic motor responses.

According to the researchers, findings revealing abnormalities in circuits important for basic motor response control may be crucial to understanding why children with ADHD have difficulty suppressing impulsive actions.

"Using LDDMM, we can more accurately measure the impact of ADHD on brain development, which will not only bring us closer to unlocking the biological basis of the disorder, but help us better diagnose and treat patients," said Dr. Stewart H. Mostofsky, senior study author and a pediatric neurologist in the Department of Developmental Cognitive Neurology at the Kennedy Krieger Institute.

The study is published in the online advance edition of The American Journal of Psychiatry.

Source: ANI
SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
Toothache
World AIDS Day 2021 - End Inequalities, End AIDS
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Attention Deficit Hyperactivity Disorder (ADHD) Parkinsons Disease Parkinsons Disease Surgical Treatment Bullying at School - Tips For Schools Brain ADHD Dyscalculia / Learning Disabilities Brain Facts Ataxia Language Areas in The Brain 

Recommended Reading
Attention Deficit Hyperactivity Disorder (ADHD)
Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder that affects normal .....
Divorce Risk High in Parents of Children With ADHD
Parents whose children suffer from attention deficit hyperactivity disorder (ADHD) are more likely ....
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Dyscalculia / Learning Disabilities
Dyscalculia is a learning disability involving mathematics. Recognized by The WHO, it affects nearl...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use