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New Target for Lung Cancer Identified

by Sheela Philomena on April 6, 2011 at 12:40 PM
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 New Target for Lung Cancer Identified

Researchers have discovered a mutation in DDR2 gene that helps to identify which patients with squamous cell lung cancer will respond to a leukemia drug called dasatinib.

According to lead researcher Matthew Meyerson, professor of pathology at the Dana Farber Cancer Institute, there are currently no targeted therapies for squamous cell lung cancer.

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Using standard genetic sequencing techniques, Meyerson and colleagues identified mutations in the DDR2 kinase gene in about 3 percent of squamous cell lung cancers and cell lines.

Furthermore, they found that tumor cells with these DDR2 mutations responded to treatment with dasatinib.

A patient whose cancer carried a DDR2 mutation also showed a clinical response to dasatinib.
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"Dasatinib is an existing therapy for chronic myelogenous leukemia with a long history and a strong safety profile," said Meyerson.

"The results of this study clearly encourage a clinical trial to test dasatinib in the setting of squamous cell lung cancer," he added.

The findings are published in Cancer Discovery.

Source: ANI
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