Cognitive disorders primarily affect cognitive abilities including learning, memory, perception, and problem solving. Investigators at The Feinstein Institute for Medical Research discovered dozens of new genetic variations associated with a person's general cognitive ability.
The findings, which were published online in Cell Reports, have the potential to help researchers develop more targeted treatment for cognitive and memory disorders.
New Insight into the Genes Responsible for Cognitive Ability
New clues into how the brain works at the molecular level has been provided by a new study.
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‘Dozens of new genetic variations associated with a person's general cognitive ability has the potential to help researchers develop more targeted treatment.’
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"For the first time, we were able to use genetic information to point us towards specific drugs that might aid in cognitive disorders of the brain, including Alzheimer's disease, schizophrenia and attention deficit hyperactivity disorder," said Todd Lencz, PhD, senior author of the study and professor at the Feinstein Institute and the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell.
In the largest peer-reviewed study of its kind, an international team of 65 scientists, led by Dr. Lencz, studied the genomes of more than 100,000 individuals who had their brain function measured by neuropsychological tests. These data were then combined with genomes from 300,000 people measured for the highest level of education achieved, which serves as an estimate for cognitive ability, or how the brain acquires knowledge.
![Chimpanzees Have the Patience and Cognitive Ability to Cook Food]( "Chimpanzees Have the Patience and Cognitive Ability to Cook Food")
If chimpanzees visualized the prospect of getting a cooked slice of sweet potato a bit later, they would give up a raw slice of sweet potato in their hand.
While profiling cognitive ability, researchers also discovered a genetic overlap with longevity. They found when examining an individual's family that a genetic predisposition towards higher cognitive ability was associated with longer lifespan. A new genetic overlap between cognitive ability and risk for autoimmune disease was also identified.
This study appears less than a year after Dr. Lencz and his colleagues published a similar, smaller study that was only able to identify a few key genes associated with cognitive ability.
"The field of genomics is growing by leaps and bounds," Dr. Lencz said. "Because the number of genes we can discover is a direct function of the sample size available, further research with additional samples is likely to provide even more insight into how our genes play a role in cognitive ability."
Source: Eurekalert
Chimpanzees Have the Patience and Cognitive Ability to Cook Food
If chimpanzees visualized the prospect of getting a cooked slice of sweet potato a bit later, they would give up a raw slice of sweet potato in their hand.
Advertisement
While profiling cognitive ability, researchers also discovered a genetic overlap with longevity. They found when examining an individual's family that a genetic predisposition towards higher cognitive ability was associated with longer lifespan. A new genetic overlap between cognitive ability and risk for autoimmune disease was also identified.
This study appears less than a year after Dr. Lencz and his colleagues published a similar, smaller study that was only able to identify a few key genes associated with cognitive ability.
"The field of genomics is growing by leaps and bounds," Dr. Lencz said. "Because the number of genes we can discover is a direct function of the sample size available, further research with additional samples is likely to provide even more insight into how our genes play a role in cognitive ability."
Source: Eurekalert
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