A single dose of an anti-inflammatory treatment was found to reduce heart muscle damage during angioplasty procedures, says study.
What is a heart attack / How to prevent heart attacks
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed.
Heart attack is the death of the heart muscle due to loss of blood supply. Simple guidelines to avoid heart attack are listed.
CK-MB levels dropped 16.3 percent more after 16 hours and 17.4 percent more at 24 hours, compared with patients on placebo.
"It was exciting to see that a single administration of inclacumab would yield clinical benefit," said the study's lead investigator Jean-Claude Tardif, director of the Research Center at the Montreal Heart Institute.
The phase II trial examined 530 patients with a median age of 61 experiencing a type of heart attack called non-ST-elevation myocardial infarction or NSTEMI.
Patients were randomized to receive an infusion of inclacumab of 20 milligrams per kilogram, five milligrams per kilogram or a placebo one hour before angioplasty.
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Angioplasty
Arteries supplying the heart is sometimes blocked by plaque leading to heart attack.Angioplasty is a method by which a part of the blocked artery is expanded to place a stent.Once this is done normal blood flow resumes and the heart regains its normal function.
Arteries supplying the heart is sometimes blocked by plaque leading to heart attack.Angioplasty is a method by which a part of the blocked artery is expanded to place a stent.Once this is done normal blood flow resumes and the heart regains its normal function.
Many clinical trials define that threshold as the onset of a post-angioplasty heart attack.
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Brain Angioplasty Safe, Effective for Stroke Patients
Stroke patients may benefit from cerebral angioplasty and stent placement, finds study published in the journal Radiology.
Stroke patients may benefit from cerebral angioplasty and stent placement, finds study published in the journal Radiology.
"If we're able to confirm these results in potential future studies, this drug could become part of the therapeutic armamentarium in modern cardiology," Tardif said in a statement.
"You could use this drug more widely, in all patients coming in with heart attacks, although that would require additional large studies."
More than a million coronary angioplasty procedures are performed in the United States each year, costing more than $10 billion.
Angioplasty can damage heart tissue, which can trigger a need for more procedures, poor outcomes and higher health care costs .
During angioplasty, surgeons insert a balloon catheter to mechanically widen narrowed or obstructed arteries.
Source-AFP
