About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Dosing Guideline to Treat Bipolar Depression Symptoms in Pregnant Women

by Thilaka Ravi on November 2, 2013 at 6:59 PM
Font : A-A+

New Dosing Guideline to Treat Bipolar Depression Symptoms in Pregnant Women

New Northwestern Medicine research reports one of the first in-depth studies of how physiological changes during pregnancy reduce the effects of a commonly used drug to treat bipolar disorder, thus making women more vulnerable to recurring episodes. The new findings will help psychiatrists and physicians prevent bipolar manic and depressive symptoms during pregnancy, which are risky for the health of the mother and her unborn child.

When a woman with bipolar disorder becomes pregnant, she and her physician often don't realize her medication needs adjusting to prevent the symptoms from coming back - a higher risk during pregnancy. There also is little information and research to guide dosing for psychiatric medications during pregnancy.

Advertisement

Approximately 4.4 million women in the U.S. have bipolar disorder with women of childbearing age having the highest prevalence.

The new study shows the blood concentration of the commonly used drug lamotrigine decreases in pregnant women. About half of the women in the study had worsening depressive symptoms as their lamotrigine blood levels dropped. The drug levels fall because women have increased metabolism during pregnancy.
Advertisement

"Now physicians change the dose of the drug in response to women's symptoms worsening," said lead investigator Crystal Clark, M.D., an assistant professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and a psychiatrist at Northwestern Memorial Hospital. "We need to optimize their medication dosing so they stay well."

The study results will help physicians understand how to increase their patients' doses during pregnancy and then reduce them postpartum to avoid toxicity, Clark said. Guidelines for prescribing the drug for pregnant women with the disorder also are included.

The study was published Nov. 1 in the American Journal of Psychiatry.

Depressive episodes -- as opposed to manic -- are most likely to recur in pregnant women with bipolar disorder.

"The safety of the fetus is at risk," Clark said. "Pregnant women that are depressed are less likely to take care of themselves which often leads to poor nutrition, lack of compliance with prenatal care and isolation from family and friends. It has also been linked to premature births and babies with low birth weights among other poor birth outcomes."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Link between Dietary Intake of Plant-based Essential Fatty Acids and Death Risk
Aspirin may be Harmful When Used for Preventing 1st Heart Attack, Stroke
Pregnancy Complications Elevated Among Symptomatic COVID-19 Women
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Adolescence Depression Depression Breech Presentation and Delivery Stress Relief Through Alternative Medicine Andropause / Male Menopause Pregnancy and Complications Bereavement Anemia in Pregnancy Iron & Folate Deficiency Anemia In Pregnancy Diet for Anemia in Pregnancy 

Recommended Reading
Psychological Changes In Pregnancy
Pregnancy is an experience of growth, change, enrichment and challenge. During the 40 weeks of ......
Tips For Pregnant Women
Pregnancy is a time when a female blossoms into a woman with an experience never felt before. Here ....
Drugs in Pregnancy and Lactation
During pregnancy & lactation a nutritious diet, suitable exercise, adequate rest and a tranquil ......
Depression Calculator
A quick, simple and anonymous self-assessment health tool to assess the level of depression using .....
Andropause / Male Menopause
Andropause or male menopause causing low libido in a man is due to decreasing level of male hormones...
Anemia in Pregnancy
Anemia is the commonest blood disorder that may occur in pregnancy and is usually due to low iron or...
Bereavement
Bereavement refers to grief, pain and sadness following the loss of a loved one, especially during t...
Breech Presentation and Delivery
Breech birth or presentation is delivery of the fetus in a bottom or foot-first position. Causes of ...
Depression
Depression is one of the most common mental disorders affecting approximately 340 million people in ...
Diet for Anemia in Pregnancy
A modified diet rich in Folate, Vitamin B12 and Iron is essential for the rapid rise in hemoglobin ....
Iron & Folate Deficiency Anemia In Pregnancy
About 95% of the anemia cases are due to iron deficiency....
Pregnancy and Complications
In-depth guide for expecting mothers to overcome health complications related to early or late pregn...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use