Schizophrenia is one of the most disabling psychiatric diseases and affects approximately 1% of the population. It’s onset commonly takes place in late adolescence and is often a life-long condition with symptoms such as delusions, hallucinations, and anxiety. The disease mechanisms are largely unknown, which has hampered the development of new drugs. The drugs currently available are designed to alleviate the symptoms, but are only partly successful, as only 20% of the patients become symptom-free.
‘Schizophrenia patients have lower levels of the vital neurotransmitter GABA as well as changes in the brain's immune cells.’
Researchers at Karolinska Institutet collaborating in the large-scale
Karolinska Schizophrenia Project are taking an integrative approach to
unravel the disease mechanisms of schizophrenia. In the very first
results now presented in the prestigious scientific journal Molecular Psychiatry,
the researchers show that patients with schizophrenia have lower levels
of the vital neurotransmitter GABA as well as changes in the brain’s
immune cells.The Karolinska Schizophrenia Project (KaSP) brings together researchers from a number of different scientific disciplines to build up a comprehensive picture of the disease mechanisms and to discover new targets for drug therapy. Patients with an acute first-episode psychosis are recruited and undergo extensive tests and investigations. Cognitive function, genetic variation, biochemical anomalies as well as brain structure and function are analyzed using the latest techniques and then compared with healthy peers.
The first results from the project are now presented in two studies published in the journal Molecular Psychiatry. One of the studies shows that patients with newly debuted schizophrenia have lower levels of the neurotransmitter GABA in their cerebrospinal fluid than healthy people and that the lower the concentration of GABA the more serious their symptoms are.
GABA is involved in most brain functions and along with glutamate it accounts for almost 90% of all signal transmission. While glutamate stimulates brain activity, GABA inhibits it, and the two neurotransmitters interact with each other.
"Over the years, animal studies have suggested a link between decreased levels of GABA and schizophrenia," says Professor Göran Engberg at Karolinska Institutet’s Department of Physiology and Pharmacology. "Our results are important because they clinically substantiate this hypothesis."
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"Our interpretation of the results is an altered function of immune cells in the brain in early-stage schizophrenia," says Senior lecturer Simon Cervenka at Karolinska Institutet’s Department of Clinical Neuroscience.
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KaSP is a collaboration between clinical and preclinical research groups at Karolinska Institutet and four psychiatric clinics under Stockholm County Council.
Source-Eurekalert