An orthopedic implant is often used to replace a missing joint or bone or to support a damaged bone. There have been media reports of people having allergic reactions to the metals used in joint implants.
To understand the molecular mechanisms involved in the interaction of bone with orthopedic implants comprised of novel biomaterials, researchers have made a mouse model in which they can assess early tissue responses to surfaces such as bioactive glass.
The ease of genetically modifying this mouse model makes it especially valuable in designing novel biomaterials for use in regenerative medicine, as describe in an article published in Tissue Engineering, Part C Methods, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
"This very accessible and elegant model brings the assessment of bone replacing biomaterial to a new level," says Tissue Engineering, Part C: Methods Co-Editor-in-Chief John A. Jansen, Professor Dentistry - Biomaterials, Radboud University Medical Center, Nijmegen, Netherlands.