A novel 3-D imaging tool that can provide a highly accurate method to detect non-alcoholic fatty liver disease (NAFLD) has been developed by US research team led by an Indian-origin scientist. The researchers at the University of California, San Diego, conducted a prospective study of 100 patients (56 percent women) with biopsy-proven NAFLD to assess the efficacy of two-dimensional magnetic resonance elastography (MRE) and a novel 3D version. They found that both MRE technologies were highly accurate for diagnosing advanced fibrosis, with 3D perhaps providing additional capabilities in some patients. ‘The new 3-D magnetic resonance elastography (MRE) tool creates images that measure the stiffness of the liver tissue, which is an indicator of fibrosis.’ "3D MRE is probably the most accurate non-invasive method to detect advanced fibrosis," said Rohit Loomba, the study's first author and director of the NAFLD Research Centre at UC San Diego School of Medicine. MRE is a specialized version of magnetic resonance imaging (MRI) that propagates mechanical shear waves in liver tissue. An algorithm creates images that quantitatively measure tissue stiffness -- an indicator of fibrosis. The 2D version of MRE is already commercially available and easily implemented on basic MRI systems in clinics. Three-dimensional MRE is more technically demanding and not yet widely available. The findings of the study, published recently in the American Journal of Gastroenterology, are encouraging because diagnosing NAFLD can be challenging. Current non-invasive techniques, such as molecular biomarkers in blood, are not sufficiently accurate for routine clinical use. Ultrasound-based methods have high failure rates, particularly in obese patients. "These findings suggest that MRE could be used to enroll patients with advanced fibrosis into screening programs for cirrhosis as well as enrollment into clinical trials aimed at reversing fibrosis in the setting of advanced fibrosis," Loomba said. Source: IANS << App Diagnoses Respiratory Diseases Through a Cough Into a Sm... Cigarette Smoke and Flu Virus may Reduce the Efficacy of Lun... >> Recommended Reading Our Chairs are Slowly Killing Us As Prolonged Sitting Is Linked With Fatty Liver Disease Our body is designed to move and it is not surprising that sedentary behavior, characterized by low muscle activity, has a direct impact on physiology. READ MORE Transplant Drug Helpful for Patients With Progressive Liver Disease The drug, mycophenolate mofetil seems safe and effective in treating autoimmune hepatitis (AIH), indicates a new research. READ MORE University of California Launches Liver Disease Research Center The non-alcohol fatty liver disease Research Center was launched to better understand the disease and develop treatments where none currently exist. READ MORE Drug Used To Treat Liver Disease Could Also Be Effective In Treating Parkinson’s Disease UDCA drug improved mitochondrial function which is affected in Parkinson's disease by increasing oxygen consumption and cellular energy levels. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia The Essence of Yoga Blood Donation - Recipients Accident and Trauma Care More News on: Hepatitis ALiverWilson's DiseaseMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?