About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Natural Protective Factors May Help Reduce Inflammation

by Bidita Debnath on September 24, 2017 at 10:54 PM
Font : A-A+

 Natural Protective Factors May Help Reduce Inflammation

Chronic inflammation can eventually cause several diseases and conditions. In type 2 diabetes, chronic inflammation drives cardiovascular disease, the leading cause of death among people with the condition.

Researchers at Joslin Diabetes Center now have identified an unexpected natural protective factor that works against this inflammation.

Advertisement


Scientists have long known that in diabetes, high levels of glucose and lipids (cholesterol and triglycerides) trigger white blood cell called monocytes to move into artery walls and evolve into other cells known as macrophages. These cells engulf lipids but then end up stuck on the artery walls, eventually producing atherosclerosis (a narrowing and thickening of the walls).

During this process, the high levels of glucose and lipids also activate multiple forms of a molecule called protein kinase C (PKC), which help these unhelpful macrophages to activate, survive and multiply, thus boosting inflammation.
Advertisement

In experiments with a mouse model of type 2 diabetes, however, the Joslin investigators showed that one form of the PKC molecule called PKC-delta actually defends against this inflammation process, by suppressing the population of macrophages gone wrong.

"The complete surprise to us was that although most forms of PKC make inflammation worse, PKC-delta happens to be the opposite, a natural protective mechanism," says George King, M.D., Joslin Chief Scientific Officer and corresponding author on a paper describing the work published in the journal Circulation Research.

Follow-up work in cell cultures by King's lab showed that this defensive role for PKC-delta is triggered by high levels of lipids rather than glucose. That finding suggests that the molecule also may help to prevent inflammation in related metabolic conditions such as obesity and metabolic syndrome.

Additionally, the scientists discovered a mechanism by which PKC-delta inhibits a biological pathway that protects cells from dying.

This early study in animal models suggests that it may eventually be possible to reduce inflammation by activating PKC-delta in human monocytes, says King, who is also a professor of medicine at Harvard Medical School.

However, he points out that activating this molecule will create different effects in different parts of the body.

Work published last year by his lab, for example, suggested the possibility of treating slow-healing wounds by a cell-therapy approach that suppresses PKC-delta production in connective-tissue cells. Other research in the lab of Joslin's C. Ronald Kahn, M.D., showed that inhibiting PKC-delta in the liver might aid in overcoming insulin resistance, a key contributor to type 2 diabetes and metabolic syndrome.

These varied roles for PKC-delta indicate that for any potential future therapies, "we need to target treatment to specific tissues," he emphasizes.

King's latest research also highlights a major continuing theme for Joslin research. "There are protective factors and risk factors for diabetes complications," he says. "We need to have equal focus on stimulating the protective factors as well as limiting the risk factors."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anti-Inflammatory Diet Inflammation Top Ten Foods That Trigger Inflammation 

Recommended Reading
Cardiovascular Disease Risk Linked to Income and Access to Healthy Food
People living in food deserts were likely to smoke, had a higher prevalence of high blood pressure ....
Hormone Therapy Not Linked to Mortality from Cardiovascular Disease
No link found between hormone therapy and mortality from cardiovascular disease and cancer in ......
Genomic-based Diagnostic Approach may Help Treat Cardiovascular Diseases
Heart attacks and strokes are usually acute events and are mainly caused by a blockage that ......
Ozone Exposure Linked With Cardiovascular Disease
Ozone is a difficult pollutant to control because its creation in the atmosphere is complex....
Anti-Inflammatory Diet
Healthy foods as part of anti-inflammatory diet to fight inflammation are basic components of the Me...
Inflammation
Inflammation is the response of living tissue to injury due to a variety of causes that call upon ho...
Top Ten Foods That Trigger Inflammation
Foods like refined carbohydrates, sugar, certain types of fat, artificial food additives and alcohol...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)