Medindia
Advertisement

Multi-organ-on-a-chip System Evaluates Chemotherapy Toxicity

by Colleen Fleiss on June 21, 2019 at 12:03 AM

Multi-organ-on-a-chip System Evaluates Chemotherapy Toxicity
A new multiorgan-on-a-chip system that can accurately capture the toxic effects of chemotherapies has been created by Christopher McAleer and colleagues.

The technology could help scientists measure both the effectiveness and potential side effects of existing and new drugs faster and more accurately compared to standard preclinical models. Drug candidates tested using animal models have a high clinical failure rate, and safety studies based on individual human cells can miss toxicity in larger organ systems such as the liver and heart. As a result, candidates with an initially promising safety profile can perform poorly in clinical trials due to unanticipated and damaging side effects.
Advertisement


Their system contains five chambers that can house different populations of human cancer and organ cells, some of which are grown on electrical modules, in a recirculating medium that mimics blood circulation. Importantly, the system can be easily and quickly adapted by inserting new chips in different compartments, allowing for flexible testing of different organ systems.

Experiments revealed the chemotherapy diclofenac exerted toxic effects on liver cells (reducing liver viability by 30%) in a system representing bone marrow cancer. In a different configuration, the chemotherapy tamoxifen affected the function of heart cells and was more effective against drug-resistant vulva cancer when combined with the blood pressure drug verapamil.

In addition to its potential uses in drug testing, the chip model could find applications in the design of personalized therapies by integrating patient-derived cells, the authors say.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chronic Lymphocytic Leukemia Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Peritoneal Cancer Rhabdomyosarcoma Male Breast Cancer Ciguatera - Fish Poisoning Tumor Lysis Syndrome 

Recommended Reading
Chemotherapy Drugs
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body....
Quiz on Chemotherapy Drugs
Chemotherapy involves the administration of medications to fight cancer. Test your knowledge on .....
Patients Who Received PBI Without Chemotherapy Experienced Less Fatigue, Slightly Poorer Cosmesis: Study
PBI Vs. WBI: Women with breast cancer who received partial breast irradiation (PBI) without ......
Less Chemotherapy Better for Older Patients With Some Advanced Cancers: Study
Less chemotherapy is as effective at controlling disease for elderly or frail patients with ......
Chemotherapy
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Ciguatera - Fish Poisoning
Ciguatera is a type of food poisoning caused due to the consumption of fish infected with a marine t...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Male Breast Cancer
Most cases of male breast cancer are diagnosed between the ages of 60 and 70 years. Treatment of mal...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Peritoneal Cancer
Peritoneal cancer is a rare cancer that develops in the peritoneum. Peritoneal cancers may be primar...
Rhabdomyosarcoma
Rhabdomyosarcoma is a rare type of cancer affecting the striated muscles. It mostly occurs in ......
Tumor Lysis Syndrome
Tumor lysis syndrome is a collection of metabolic abnormalities due to the tumor cell lysis in patie...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use