New body-on-a-chip model reliably evaluates both on- and off-target effects of chemotherapies on multiple organs simultaneously.

‘New body-on-a-chip model reliably evaluates both on- and off-target effects of chemotherapies on multiple organs simultaneously.’

Their system contains five chambers that can house different populations of human cancer and organ cells, some of which are grown on electrical modules, in a recirculating medium that mimics blood circulation. Importantly, the system can be easily and quickly adapted by inserting new chips in different compartments, allowing for flexible testing of different organ systems. 




Experiments revealed the chemotherapy diclofenac exerted toxic effects on liver cells (reducing liver viability by 30%) in a system representing bone marrow cancer. In a different configuration, the chemotherapy tamoxifen affected the function of heart cells and was more effective against drug-resistant vulva cancer when combined with the blood pressure drug verapamil.
In addition to its potential uses in drug testing, the chip model could find applications in the design of personalized therapies by integrating patient-derived cells, the authors say.
Source-Eurekalert