About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Mount Sinai Scientists Assess Accuracy of Commercial Lab Tests

by Bidita Debnath on March 31, 2016 at 12:00 AM
Font : A-A+

 Mount Sinai Scientists Assess Accuracy of Commercial Lab Tests

At Mount Sinai, scientists from the Icahn School of Medicine performed an in-depth comparison of basic blood tests run by commercial laboratories to assess comparability of the tests among the different laboratories, finding that testing service and time of collection significantly influenced results.

Given that lab tests are used to help decide everything from disease diagnosis to whether a patient needs medicine or whether that medication is working, this study highlights the importance of knowing the accuracy and variability of test results.

Advertisement


The IRB-approved research study, which was first designed in early 2015 with data collected last July, analyzed results from comparable blood tests on healthy adults conducted at LabCorp, Quest Diagnostics, and Theranos. Researchers collected multiple samples from the same individuals and controlled for variables such as age, sex, and time of blood collection, among many others, but still found that more than half of test results showed significant differences between test providers.

Triglyceride levels and red blood cell counts were among the most consistent results, while white blood cell counts and overall cholesterol levels were among the most variable. Test results from Theranos were flagged by Theranos as abnormal 1.6 times more often than those from LabCorp or Quest. Data from blood samples collected earlier in the day also showed significant differences compared to samples from the same subjects later in the day. The study was published today in the Journal of Clinical Investigation.
Advertisement

"While most of the variability we found was within clinically accepted ranges, there were several cases where inaccurate results would have led to incorrect medical decisions," said Joel Dudley, senior author on the paper and Director of Biomedical Informatics at the Icahn School of Medicine at Mount Sinai. "We hope this study will inspire the biomedical community to take a critical look at all testing variables to ensure that lab results are as robust and reproducible as possible."

The study focused on common blood tests, which typically return a single data point or a few data points. However, as Mount Sinai scientists showed, even standard blood tests can generate rich data for statistical analysis: this study collected 14 samples to generate 22 lab results for each of 60 subjects, leading to a total of more than 18,000 data points in this project alone. While most results were within normal ranges, having even a small amount of inaccurate data mixed in could lead to erroneous conclusions from scientific or clinical studies.

"These testing disparities occurred despite rigorous laboratory certification and proficiency standards designed to ensure consistency," said co-senior author Eric Schadt, PhD, the Jean C. and James W. Crystal Professor of Genomics at the Icahn School of Medicine at Mount Sinai, and Founding Director of the Icahn Institute for Genomics and Multiscale Biology. "Our results suggest the need for greater transparency in lab technologies and procedures, as well as a much more thorough investigation of biological mechanisms that may contribute to more dynamic levels than we currently understand."

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

Most Popular on Medindia

A-Z Drug Brands in India Drug - Food Interactions Blood Donation - Recipients Calculate Ideal Weight for Infants Hearing Loss Calculator Selfie Addiction Calculator Sanatogen Diaphragmatic Hernia Drug Side Effects Calculator Loram (2 mg) (Lorazepam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Mount Sinai Scientists Assess Accuracy of Commercial Lab Tests Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests