Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure, revealed a new study.
Kidney Failure due to Melamine Toxicity
Adulteration of food with melamine results in the formation of kidney stones and kidney failure, even leading to death.
Adulteration of food with melamine results in the formation of kidney stones and kidney failure, even leading to death.
‘Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure.’
Levels of four metabolites in the blood- 4-hydroxyphenylacetate, phenylacetylglutamine, hippurate, and prolyl-hydroxyproline- were associated with impaired cognitive function. The first three are primarily produced by bacteria that reside in the gut. When the researchers screened for the metabolites in an additional 180 patients with kidney failure, the association between 4-hydroxyphenylacetate and impaired cognitive function was replicated. "This metabolite has been previously linked to cognitive impairment in patients with liver failure and in patients with inborn errors of urea synthesis," said Dr. Tamura. "We believe these findings are timely, given recent interest in the role of the gut microbiome in human disease."
Source-Newswise
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