About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Medical Community Raises Questions on the Safety of Stored Blood For Transfusions

by Tanya Thomas on April 18, 2011 at 9:18 AM
Font : A-A+

 Medical Community Raises Questions on the Safety of Stored Blood For Transfusions

In light of recent studies that suggest the use of stored blood during transfusions may cause adverse effects in patients, the National Heart, Lung, and Blood Institute (NHLBI) funded a number of research projects to examine the safety of transfusing older red cells and the impact of stored blood on respiratory gases. These papers discussing potential adverse effects of stored blood and related concerns for oxygen delivery by transfusion are now available online in TRANSFUSION, a journal published by Wiley-Blackwell on behalf of AABB.

Blood banks are responsible for the collection, testing, and storage of blood to be used by the nearly 5 million Americans who receive blood transfusions annually. When patients experience a loss of blood due to illness or trauma, transfusions of whole blood or individual components (red cells, white cells, platelets, and plasma) are administered to restore blood volume to adequate levels. According to the 2007 National Blood Collection and Utilization Survey (NBCUS) Report, 14.7 million units of blood were administered in the U.S., with a total of 72,000 transfusion-related adverse reactions in the prior year.

Advertisement

"The most critical issue facing transfusion medicine is whether or not stored (older) blood is less safe than fresher blood," explains Paul M. Ness, M.D., Director of Transfusion Medicine at Johns Hopkins Medical Institute in Baltimore, MD, and Editor-in-Chief of TRANSFUSION. "Although emerging infectious disease risks and transfusion reactions are important concerns, there is nothing more imperative to our patients than making sure the methods we use to collect and store red cells do not impair their transport of vital respiratory gases."

Current Food and Drug Administration (FDA) standards state that red cells may be stored under refrigeration for a maximum of 42 days, or frozen for up to ten years. NBCUS 2007 data reported the mean age of stored red cells at the time of transfusion was 16 days. Medical evidence, however, has not been able to conclusively determine if stored blood adversely affects patients' health. In one prior study, trauma patients who received red cells stored beyond two weeks had a significantly increased risk of mortality compared to those transfused with fresher blood (Weinberg et al., 2010). Conversely, a study by Edgren et al., analyzed close to 405,000 transfusions between 1995 and 2002 and found no significant association between age of blood and seven-day mortality.
Advertisement

Controlled clinical trials in cardiac surgery and intensive care units are under way, and are expected to provide the transfusion community with critical data regarding the adverse effects of stored blood use. "Findings from these trials will not be reported for several years," said Dr. Ness. "Our early publication of the NHLBI grant program studies provides the transfusion community with a head start in learning more about what makes stored blood old, and provides advance opportunity for commercial industry to develop improved methods of blood storage that will mitigate adverse effects in patients."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Ways to Manage Stress during COVID-19 Pandemic
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Blood in Stools - Symptom Evaluation Bombay Blood Group 

Recommended Reading
Coming Soon, Blood Transfusions That Require No Typing
An "important step" toward development of a universal blood product that would eliminate the need .....
Wrong Blood Transfusion Leads to Fetal Death
Gross negligence led to fetal death due to wrong blood transfusion to an expectant mother....
Comparative Outcomes Seen With Restrictive Use of Blood Transfusions During Cardiac Surgery
A study in JAMA says that use of stricter guidelines for the use of red blood cell transfusio...
Consent from Patients Should be Sought Before Blood Transfusions: Experts
Two legal experts argue on bmj.com today that informed consent should be obtained from competent ......
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use