About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Low-fat Diet with Calorie Restriction Helps Prevent Aging

by Hannah Joy on March 12, 2018 at 4:54 PM
Font : A-A+

Low-fat Diet with Calorie Restriction Helps Prevent Aging

Consuming a low-fat diet in combination with caloric restriction can help prevent activation of the brain's immune cells called microglia, reveals a new study.

The study also finds that exercise is significantly less effective than caloric restriction in preventing these age-related changes. The research was published in Frontiers in Molecular Neuroscience.

Advertisement


" Obesity and aging are both prevalent and increasing in societies worldwide, but the consequences for the central nervous system are not well understood," says Bart Eggen, lead author of the study and a researcher at the University Medical Center Groningen, The Netherlands.

"We determined if a high- or low-fat diet , in combination with exercise and food restriction, impacted microglia during aging in mice."
Advertisement

Microglia are brain cells that help maintain the integrity and normal functioning of brain tissue. Dysfunction of these cells, as may occur in disease, is linked to neurodevelopmental disorders and neurodegenerative conditions.

Aging is also associated with inflammation driven by microglia in specific regions of the brain, but it is unclear whether diet or lifestyle can influence this process.

Eggen and his collaborators investigated the impact of high- and low-fat diets on inflammation and microglial markers in a specific brain region the hypothalamus of 6-month-old mice. They further looked at the effect of low- or high-fat diets on the microglia of 2-year-old mice, which were also given a lifelong exercise regime (voluntary running wheel) or lifelong restricted diets (a 40% reduction in calories).

"Aging-induced inflammatory activation of microglia could only be prevented when mice were fed a low-fat diet in combination with limited caloric intake," says Eggen. "A low-fat diet per se was not sufficient to prevent these changes."

The researchers also found that exercise was significantly less effective than caloric restriction at preventing these changes, although work by others has shown that exercise is associated with reducing the risk of other diseases.

Eggen is careful to point out that there is still much more work needed to understand the meaning of these findings.

In their study, mice were only given one type of diet throughout their lives. It remains unclear how changing between diets would alter these results, for example whether switching to a low-fat diet could undo the negative consequences of a high-fat, unrestricted diet.

Further studies are also needed to determine how these changes correspond to the cognitive performance of the mice.

"Nevertheless, these data do show that, in mice, the fat content of a diet is an important parameter in terms of the detrimental effects of aging on the brain, as well as caloric intake," says Eggen.

"Only when fat content and caloric intake are limited, can aging-induced changes in microglia be prevented."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diet Pills Low Calorie Diet Low Carbohydrate Diet Atkins Diet The Cabbage Diet South Beach Diet Negative Calorie Diet Bulimia Nervosa Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease 

Recommended Reading
The Healthy Way of Eating with Sattvic Diet
Sattvic diet is an ancient practice that is followed in Ayurveda. It is the purest form of food ......
The Ornish Diet Essentials
Dr. Ornish is associated with the prevention of heart disease. This article will describe and ......
Vegan Way to Lose Weight and Reverse Disease
The best way to lose weight and reverse disease could be to jump into a completely dairy-free, ......
Figure Foods
There are foods researched by nutrition science which exert effects in such a way that the body is ....
Atkins Diet
Atkins diet is a low carbohydrate diet and aids in weight loss. It was developed by Robert Atkins....
Bulimia Nervosa
The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followe...
Diet Pills
Diet pills are flooding the market by millions. The positive side of diet pills to most people is th...
Low Calorie Diet
Low calorie meals or diet include foods that are high on nutritional content and yet have fewer calo...
Low Carbohydrate Diet
A low carbohydrate diet helps achieve weight loss. It is a diet plan that restricts the carbohydrate...
Negative Calorie Diet
The History of dieting probably dates back to the year 1807. It was believed that King William sudde...
South Beach Diet
South Beach Diet plan originally developed to prevent heart disease, soon gained popularity as weigh...
The Cabbage Diet
The plausible reason that can be sited is the inherent low calorie property of cabbage....
Why Do We Eat - Nutrition Facts
The importance of eating food and the physiological, psychological and social functions of food....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use