An association between the brain's network connections and grey matter atrophy caused by certain types of epilepsy has been discovered by researchers.
In neuroscience, brain's connectome is as important as its anatomy when studying human disease. The connectome is a map of neural connections that describes how brain regions interact and work together to perform certain tasks.
Epilepsy During Pregnancy
Seizures or epilepsy during pregnancy can be fatal for both the mother and child and needs urgent medical intervention. The reasons are often unknown.
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‘The new model could predict the damage the epilepsy did to the grey matter of individual patients over time.’
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The Neuro (Montreal Neurological Institute-Hospital) researchers analyzed data from 1,021 individuals with epilepsy and 1,564 healthy controls over 19 sites around the world from the ENIGMA database. The database is a collection of neuroimaging data available to researchers under Open Science principles. Researchers used the data to map grey matter atrophy, a characteristic of epilepsy, in the patients.
They then collected data from another database called the Human Connectome Project, which provides connectome data from a large group of healthy controls.
![Quiz on Fits]( "Quiz on Fits")
Fits or Seizures could happen due to a number of reasons. Not all fits qualify to being labeled as epilepsy. Fits manifest in various forms. Test your knowledge on fits by taking this quiz.
Their hypothesis was that grey matter atrophy would appear most often in parts of the brain where connectivity was highest. These regions are known as hubs.
"Hub regions are known to participate in brain signalling, have high plasticity, and high metabolic activity, making them a candidate for epilepsy-related atrophy," says Sara Larivière, the study's lead author and a PhD candidate at The Neuro.
Study found that areas of high atrophy in patients with both idiopathic generalized epilepsy and temporal lobe epilepsy also tended to be hub regions.
"Our multi-site findings show that brain connectivity contributes to the effect that epilepsy has on whole brain structure," says Boris Bernhardt, a researcher at The Neuro and the study's senior author. "This will be important to understand common functional deficits in individual patients and to assess the effect of the disease over time."
Source: Medindia
Quiz on Fits
Fits or Seizures could happen due to a number of reasons. Not all fits qualify to being labeled as epilepsy. Fits manifest in various forms. Test your knowledge on fits by taking this quiz.
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Their hypothesis was that grey matter atrophy would appear most often in parts of the brain where connectivity was highest. These regions are known as hubs.
"Hub regions are known to participate in brain signalling, have high plasticity, and high metabolic activity, making them a candidate for epilepsy-related atrophy," says Sara Larivière, the study's lead author and a PhD candidate at The Neuro.
Study found that areas of high atrophy in patients with both idiopathic generalized epilepsy and temporal lobe epilepsy also tended to be hub regions.
"Our multi-site findings show that brain connectivity contributes to the effect that epilepsy has on whole brain structure," says Boris Bernhardt, a researcher at The Neuro and the study's senior author. "This will be important to understand common functional deficits in individual patients and to assess the effect of the disease over time."
Source: Medindia
Epilepsy
Fits or convulsions or Epilepsy is characterized by recurrent, involuntary seizures and is described as a chronic neurological disorder
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 Improved Treatment for Epilepsy, Depression Using Mathematical Brain ModelingMathematical modeling of the brain cells electrochemical processes using focused ultrasound will assist in the treatment of neurological conditions like epilepsy and ultrasound. | Advertisement
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