Lifespan Extension at Low Temperatures is Genetically Controlled

But a new study from Gribble's lab indicates that it's not just a matter of turning down the thermostat. Rather, the extent to which temperature affects lifespan depends on an individual's genes. Gribble's study, published in Experimental Gerentology, was conducted in the rotifer, a tiny animal that has been used in aging research for more than 100 years.

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However, the median lifespan increase ranged from 6 percent to 100 percent across the strains, they found. They also observed differences in mortality rate. Gribble's study clarifies the role of temperature in the free-radical theory of aging, which has dominated the field since the 1950s.

"Generally, it was thought that if an organism is exposed to lower temperature, it passively lowers their metabolic rate and that slows the release of ROS, which slows down cellular damage. That, in turn, delays aging and extends lifespan," Gribble says.

Her results, however, indicate that the change in lifespan under low temperature is likely actively controlled by specific genes. "This means we really need to pay more attention to genetic variability in thinking about responses to aging therapies," she says. "That is going to be really important when we try to move some of these therapies into humans."

Source: Eurekalert