Learning Strength and Motor Activity Decline in Aging Worms

The cause of increasing weakness and decline of motor activity in aging tiny worms and a way to slow it down identified in a recent study. The research aimed at targeting a molecule to enhance motor functions. The study published in Science Advances indicates that similar kinds of pathways occur in aging mammals as well.// As humans and animals age, our motor functions progressively deteriorate. Millimeter-long roundworms called nematodes exhibit aging patterns remarkably similar to those of other animals, and they only live about three weeks, making them an ideal model system for studying aging.

"We previously observed that as worms age, they gradually lose physiological functions," said Shawn Xu, professor at the LSI and senior study author. "Sometime around the middle of their adulthood, their motor function begins to decline. But what causes that decline?"

To better understand how the interactions between cells changed as worms aged, Xu and his colleagues investigated the junctions where motor neurons communicate with muscle tissue.

They identified a molecule called SLO-1 (for "slowpoke potassium channel family member 1") that acts as a regulator for these communications. The molecule dampens neurons' activity, slowing down the signals from neurons to muscle tissue and reducing motor function.

The researchers manipulated SLO-1, first using genetic tools and then using a drug called paxilline. In both cases, they observed two major effects in the roundworms. Not only did they maintain better motor function later in life, they also lived longer than normal roundworms.

"It's not necessarily ideal to have a longer lifespan without improvements in health or strength," said Xu, who is also a professor of molecular and integrative physiology at the U-M Medical School. "But we found that the interventions improved both parameters--these worms are healthier and they live longer."

Perhaps more surprisingly, the timing of the interventions drastically changed the effects on both motor function and lifespan. When SLO-1 was manipulated early in the worms' life, it had no effect on lifespan and in fact had a detrimental effect on motor function in young worms. But when the activity of SLO-1 was blocked in mid-adulthood, both motor function and lifespan improved.

Because the SLO-1 channel is preserved across many species, Xu hopes these findings will encourage others to examine its role in aging in other model organisms.

"Studying aging in organisms with longer lifespans is a major investment," he said. "But now we have identified a molecular target, a potential site and specific timing, which should facilitate further investigation."

The researchers next hope to determine the importance of the SLO-1 channel in early development in the worms and also to better understand the mechanisms through which it affects lifespan.



Source-Eurekalert