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With the aid of evolutionary clues, scientists have determined the complex process involved in blood clotting after injury.
von Willebrand Disease (vWD)
von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from birth and affects both sexes.
von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from birth and affects both sexes.
Made in cells that form the inner lining of blood vessels, VWF circulates in the blood seeking out sites of injury.
When it finds them, its helical tube unfurls to catch platelets and form blood clots.
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"The challenge for the cell is how to build this massive protein without clogging the machinery," said J. Evan Sadler, MD, PhD, professor of medicine and senior author of the study.
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"Without VWF, you bleed," he added.
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Sadler's group gathered the DNA sequences of VWF for humans, 19 other placental mammals, a marsupial, two birds, a reptile, an amphibian and five fish.
The study was published in July in the Journal of Biological Chemistry.
Source-ANI
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