About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

IVF Embryos - a Source for Red Blood Cells

by Rathi Manohar on August 17, 2010 at 7:51 PM
Font : A-A+

IVF Embryos - a Source for Red Blood Cells

Human red blood cells have been developed for the first time from embryonic stem cells by Brtish scientists working on a project to manufacture synthetic blood on an industrial scale.

The aim of the 3million project is to develop an alternative source of O-negative blood, the universal donor group that can be transfused into the vast majority of the population without fear of rejection.

Advertisement

The project, funded by the Wellcome Trust, has used more than a hundred spare IVF embryos from fertility clinics to establish several embryonic stem cell lines that replicate continuously in the laboratory.

Professor Marc Turner, leader of the project, said that synthetic blood made on an industrial scale would overcome the problem of blood shortages and the risk of transmitting new infections between donors and recipients.
Advertisement

"We've proved the principle that from these embryonic stem cell lines we can generate red blood cells," the Independent quoted Turner as saying.

"At the end of this three-year period we would envisage generating up to a unit [a pint] of red cells from embryonic stem cells at clinical grade which fulfil all the in vitro characteristics of red cells."

As part of the process of gaining regulatory approval, the project has produced four embryonic stem cell lines deemed good enough to be used in human clinical trials - conforming to the "good manufacturing practice" (GMP) grade.

Jo Mountford, a stem cell scientist at Glasgow University, confirmed that the synthetic red cells made in her laboratory from the RC-7 embryonic stem cell line produced by Roslin Cells contained the haemoglobin pigment.

"We have cells that are clearly red so we're happy with that. We've managed to go 90 per cent down the path towards fully differentiated, adult red blood cells," said Mountford.

Mountford said that the haemoglobin in the synthetic red cells also shows signs of being more similar to foetal than adult haemoglobin, but she believes that further research will lead to mature, enucleated red blood cells with adult haemoglobin.

"We're confident that we'll get the numbers of mature red blood cells that we need for clinical trials," she said.

Only one of the four embryonic stem cells lines produced at GMP grade has been tested for its blood type, Professor Turner said.

The line, known as RC-9, is blood type B-positive and although it is not the universal donor type it can still be used for research.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
World Heart Day 2021 -
Are Black Foods the New Superfood?
Ten Fruits for Diabetics
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia In Vitro Fertilization (IVF) Infertility Parkinsons Disease Surgical Treatment Artificial Insemination Stem Cells Blood in Stools - Symptom Evaluation Bombay Blood Group Uterus Transplantation / Womb Transplantation - Advantage and Disadvantages Assisted Reproductive Technologies 

Recommended Reading
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Blood Group Calculator
Blood group calculator gives you a detailed outlook of various blood groups, and also calculates ......
Artificial Insemination
Artificial Insemination is a medical procedure usually used to treat infertility. In this procedure,...
Assisted Reproductive Technologies
Assisted reproductive technologies include all measures involving the manipulation of gametes and em...
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bombay Blood Group
Bombay blood group is a rare blood type in which the people have an H antigen deficiency. They can r...
In Vitro Fertilization (IVF)
Encyclopedia section of medindia gives a brief introduction to infertility and reproduction...
Infertility
Infertility is a condition wherein couples fail to achieve pregnancy or if the woman has been unable...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Uterus Transplantation / Womb Transplantation - Advantage and Disadvantages
Learn more about uterus or womb transplantation. Its indications, types, complications, advantages, ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use