Insulin Nasal Spray Improves Cognition Among Obese Prediabetic Teens

by Mary Selvaraj on July 10, 2019 at 5:06 PM
 Insulin Nasal Spray Improves Cognition Among Obese Prediabetic Teens

Insulin nasal spray delivers insulin directly into the brain and improves brain connections. If administered among obese and prediabetic adolescents it is found to have better cognition, memory, mood and appetite.

Researchers at the Modern Diet and Physiology Research Center and Department of Pediatrics at Yale School of Medicine are investigating whether insulin delivered directly to the brain by nasal inhalation can enhance communication between brain regions and improve cognition in adolescents with obesity and prediabetes. Led by Dr. Dana Small, preliminary findings from a two-year study suggest that intranasal insulin improves brain and cognitive function in adolescents with obesity.


Insulin is primarily recognized for its role in regulation of blood sugar and metabolism. But insulin also travels to the brain where it influences a wide range of functions including memory, mood, and appetite. In type 2 diabetes, cells throughout the body become insensitive to insulin and when this happens in the brain, it may lead to cognitive impairment and an increased risk of developing dementia later in life..

Capitalizing on the fact that intranasal inhalation of insulin delivers insulin directly to the brain, Dr. Small and her team are investigating the link between brain insulin sensitivity and cognitive function in adolescents with obesity. Preliminary cross-sectional findings presented this week at the annual meeting for the Society for the Study of Ingestive Behavior in Utrecht, Netherlands, found that intranasal insulin delivery improved performance on a memory task in adolescents with high BMI. Compared to inhalation of a placebo, the intranasal insulin also significantly increased connectivity between left and right dorsolateral prefrontal cortex - key brain areas for cognitive performance and cognitive control.

While data collection is ongoing, the preliminary cross-sectional findings suggest that not only is obesity associated with poorer memory, but that this impairment can be reversed by intranasal insulin. The researchers plan to continue this work to better understand the role of factors such as body fat levels and diabetic status on neurocognition, as well as evaluation of the effects of changes in these measures over time.

Source: Eurekalert
Font : A-A+



Recommended Readings

Latest Mental Health News

New Suicide Crisis Helpline in Canada
The Canadian government has launched 988, a new three-digit suicide crisis helpline to provide suicide prevention support.
Pickling Positivity: Lactobacillus Guards Against Anxiety, Depression
Lactobacillus unveils new avenues for therapies targeting anxiety, depression, and various mental health conditions.
Can Obsessive-Compulsive Disorder Therapy Alter Brain Activity?
Neuroimaging exposes alterations in connectivity among individuals dealing with obsessive-compulsive disorder (OCD), stated study.
How Stress Induce Emotional Overeating?
Proenkephalin, a chemical molecule present in the brain's hypothalamus, is linked to emotionally driven overeating in response to stress and threats.
From Inflation to Global Affairs- Americans are Stressed on Holidays
Americans experience stress over the holidays, due to inflation, world affairs, rising flu and COVID-19 instances, and previous holiday melt-down.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Insulin Nasal Spray Improves Cognition Among Obese Prediabetic Teens Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests