About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Infertile Worms are Protected from Infection Induced Neurodegeneration

by Dr. Trupti Shirole on November 25, 2015 at 5:01 PM
Font : A-A+

Infertile Worms are Protected from Infection Induced Neurodegeneration

Duke University researchers have suggested that infection with live, pathogenic bacteria causes neurodegeneration in the worm C. elegans. Infected worms display a number of changes that are hallmarks of neurodegeneration in aging humans and patients with illnesses such as Alzheimer's disease. The researchers also noted that infertile animals appear to be protected from neurodegeneration.

The study appears online in the Journal of Biological Chemistry.

Advertisement


Alejandro Aballay, senior study author and associate professor of molecular genetics and microbiology at Duke University School of Medicine, said, "In worms, there may be some type of signal from the sex cells or germline that plays a role in infection-induced neurodegeneration. That was definitely unexpected, though we know that infertility liberates energy that would have been spent on producing the germline and directs it toward tissue repair and other maintenance. It will be interesting to figure out how the response to pathogens fits into this scheme."

In recent years, researchers have begun to notice a problematic relationship between pathogens and neurodegeneration. Multiple studies have shown that patients living with chronic infections are particularly susceptible to neurodegenerative diseases. What appears to happen is microbes infect a patient, alerting the immune system and unleashing inflammation, which progressively destroys neurons. This unintended side effect does not benefit the microorganism, and it certainly doesn't benefit the host.
Advertisement

Because it is so difficult to study this process in humans, Aballay's lab turned to the nematode worm, C. elegans, as a model. This 1-millimeter, transparent worm has a much simpler nervous system, consisting of only 302 neurons that represent most types of neurons in the mammalian brain. It also has a rudimentary immune system.

In the laboratory, these worms typically inhabit Petri dishes covered in a lawn of E. coli bacteria, which the animals graze all day. To infect the worms, Aballay and his colleagues simply replaced the worm's typical chow with the common bacterial pathogen Pseudomonas aeruginosa. They also tagged the animals' neurons with a fluorescent label so the researchers could visualize any neurodegenerative changes associated with infection.

The researchers witnessed a number of neural changes that are hallmarks of neurodegeneration. For example, they saw beaded neurons, nerve cells with little round outgrowths that give the appearance of beads. They also found areas where the neurons, which are normally straight like an arrow, were branched or wavy.

Aballay said, "Neurons are designed to act like a straightforward superhighway that sends signals from one cell to another. These wavy neurons are more like a mountain route, where things go very slow and inefficiently because it turns and curves."

In humans, these changes would be accompanied by behavioral defects, perhaps making it harder to remember a name or where you put the car keys. In worms, the researchers found that these neural changes also had functional consequences. Normally, the animals would be able to sense and move toward their favorite treat - salt - but when their neurons were affected, so was their ability to respond to the stimulus.

Next, the researchers wanted to determine if there were any genes that could protect against infection and neurodegeneration in worms. They mutated hundreds of worms, infected them with the same pathogen as before, and then looked to see if any were resistant to infection-induced neurodegeneration. The researchers found one particularly promising candidate, which contained a mutation in a gene called mes-1. Interestingly, all the worms with this mutation lacked the sex cells needed to produce offspring.

In additional genetic studies, Aballay and his colleagues found that another gene called DAF-16 was required for resistance to neurodegeneration in these mutant animals. Its human equivalent, a gene called FOXO6, is known to function at the intersection of pathways controlling immunity, longevity and stress responses.

Aballay said, "In the future, we plan to focus more on what is happening at the level of the neuron, to understand how the neuron senses pathogenic molecules or inflammatory cues, and how sensing those cues ultimately triggers neurodegeneration."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Flu 

Most Popular on Medindia

Blood Pressure Calculator Selfie Addiction Calculator Nutam (400mg) (Piracetam) Pregnancy Confirmation Calculator Drug Interaction Checker Loram (2 mg) (Lorazepam) Sinopril (2mg) (Lacidipine) Calculate Ideal Weight for Infants Hearing Loss Calculator A-Z Drug Brands in India
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Infertile Worms are Protected from Infection Induced Neurodegeneration Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests