The importance of the neurotransmitter gamma-aminobutyric acid (GABA) in both Type 1 and Type 2 diabetes has been highlighted in two studies published by an international research team form Uppsala University in EBioMedicine.
GABA is a naturally occurring neurotransmitter sending chemical messages through the brain and the central nervous system. It regulates communication between brain cells and its role is to reduce the activity of the neurons or nerve cells.
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, symptoms, diagnosis, treatment, facts and a glossary on diabetes.
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‘The anti-inflammatory effect of GABA or gamma-aminobutyric acid, a neurotransmitter, may be important in the pancreatic islets because, as long as GABA is present, toxic white blood cells can be reduced, thus increasing the survival of the insulin-secreting beta cells.’
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Dynamic interactions between the nervous system, hormones and the immune system are continuously taking place but in diabetes this balance is disturbed.
GABA is synthesized by an enzyme called GAD from the amino acid glutamate in nerve cells but also, importantly, in the insulin-producing beta cells in pancreatic islets. GAD has two forms, GAD65 and GAD67. In type 1 diabetes, beta cells are destroyed while type 2 diabetes is associated with impaired beta cell function and insulin resistance.
![Diabetic Diet]( "Diabetic Diet")
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nutrients, but low in fat (especially saturated fat) and moderate in calories.
Patients with type 1 diabetes often have antibodies to GAD65. However, there has been no strong link between GABA and type 2 diabetes until recently when it was shown that GABA is important for maintaining and potentially also in the making of new beta cells.
The two current studies reinforce the image of GABA's importance, for both types of diabetes. The scientists used ion channels that GABA opens, the GABAA receptors, as a biological sensor for GABA, and were able to determine the effective, physiological GABA concentration levels in human pancreatic islets. They also showed that these ion channels became more sensitive to GABA in type 2 diabetes and that GABA helps regulate insulin secretion (Article 1).
The scientists then isolated immune cells from human blood and studied the effects GABA had on these cells. They show that GABA inhibited the cells and reduced the secretion of a large number of inflammatory molecules (Article 2).
The anti-inflammatory effect of GABA may be vital in the pancreatic islets since as long as GABA is present, toxic white blood cells can be inhibited, thus increasing the survival of the insulin-secreting beta cells. When the beta cells decrease in number and disappear from the islets as happens in Type 1 diabetes, then GABA consequently is also decreased and, thereby, the GABA protective shielding of the beta cells. When inflammatory molecules increase in strength, it may weaken and even kill the remaining beta cells.
In ongoing studies, the scientists now focus on clarifying the GABA signaling mechanisms in the immune cells and in the human beta cells. They will also study how existing drugs can increase, decrease or mimic the effects of GABA, says Bryndis Birnir.
Source: Eurekalert
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nutrients, but low in fat (especially saturated fat) and moderate in calories.
Advertisement
Patients with type 1 diabetes often have antibodies to GAD65. However, there has been no strong link between GABA and type 2 diabetes until recently when it was shown that GABA is important for maintaining and potentially also in the making of new beta cells.
The two current studies reinforce the image of GABA's importance, for both types of diabetes. The scientists used ion channels that GABA opens, the GABAA receptors, as a biological sensor for GABA, and were able to determine the effective, physiological GABA concentration levels in human pancreatic islets. They also showed that these ion channels became more sensitive to GABA in type 2 diabetes and that GABA helps regulate insulin secretion (Article 1).
The scientists then isolated immune cells from human blood and studied the effects GABA had on these cells. They show that GABA inhibited the cells and reduced the secretion of a large number of inflammatory molecules (Article 2).
The anti-inflammatory effect of GABA may be vital in the pancreatic islets since as long as GABA is present, toxic white blood cells can be inhibited, thus increasing the survival of the insulin-secreting beta cells. When the beta cells decrease in number and disappear from the islets as happens in Type 1 diabetes, then GABA consequently is also decreased and, thereby, the GABA protective shielding of the beta cells. When inflammatory molecules increase in strength, it may weaken and even kill the remaining beta cells.
In ongoing studies, the scientists now focus on clarifying the GABA signaling mechanisms in the immune cells and in the human beta cells. They will also study how existing drugs can increase, decrease or mimic the effects of GABA, says Bryndis Birnir.
Source: Eurekalert
Drug Delivery Systems - Use in Diabetes Management
Different types of drug delivery systems for insulin delivery have been extensively researched recently. Oral route and transdermal drug delivery systems are among the advanced drug delivery systems.
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 Metformin - Diabetes Drug with New Therapeutic UsesMetformin, a century old anti-diabetic drug used commonly to bring down blood sugar levels has other therapeutic uses like treating PCOS, aging and obesity. | Advertisement
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