The Predimed-Plus trial found that 33.7% of the patients following the hypocaloric Mediterranean diet and daily exercise showed a minimum of 5% weight loss.
Nowadays, overweight or obese patients, particularly those with metabolic syndrome, are recommended to lose weight by changing their lifestyle. The aim of these recommendations is to reduce their cardiovascular risk; however, there is no scientific evidence that this beneficial effect can be maintained in the long-term. Although low fat and low carbohydrate diets have proven effective in losing weight and improving cardiovascular risk, the benefits tend to diminish after a year.
‘The Predimed-Plus trial evaluates more than 600 patients with overweight or obesity and metabolic syndrome, and shows that the health benefits of following this healthier lifestyle are still present after one year.’
With this investigation, the researchers from the Human Nutrition Unit at the Universitat Rovira i Virgili, in collaboration with 23 other research groups in the PREDIMED-Plus study, have evaluated the changes in body weight, fat accumulation and different cardiovascular risk factors after one year in 626 patients. These patients also showed improvements in those parameters related with glucose metabolism and certain inflammatory markers, in contrast with those patients who did not follow the diet. Furthermore, for those patients with diabetes or at risk of diabetes, the benefits from these lifestyle changes were particularly high in terms of glucose control.
The researchers highlight that, in this study, the greatest weight loss has been found after 12 months, which illustrates that weight loss was maintained over time. In the light of these results, the researchers expect that this weight-loss maintenance in response to the PREDIMED-Plus lifestyle programme can provide the same or more benefits for cardiovascular disease (myocardial infarction, stroke or mortality from these causes) in the long term. In fact, this is the main objective of the PREDIMED-PLUS trial.