About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Link Between Anxiety and Alzheimer’s Disease Found
Advertisement

Link Between Anxiety and Alzheimer’s Disease Found

Font : A-A+

Highlights:
  • Higher amyloid beta burden is associated with increasing anxious-depressive symptoms.
  • Amyloid beta levels are crucially involved in Alzheimer’s disease.
  • Emerging neuropsychiatric symptoms represent an early manifestation of preclinical Alzheimer’s disease.

An association between elevated amyloid beta levels and the worsening of anxiety symptoms has been identified by recent research. The findings support the hypothesis that neuropsychiatric symptoms could represent the early manifestation of Alzheimer's disease in older adults.

Neuropsychiatric symptoms may be predictors of Alzheimer's disease
Past studies have suggested depression and other neuropsychiatric symptoms may be predictors of Alzheimer's disease's progression during its "preclinical" phase, during which time brain deposits of fibrillar amyloid and pathological tau accumulate in a patient's brain.

Advertisement

Link Between Anxiety and Alzheimer’s Disease Found

This phase can occur more than a decade before a patient's onset of mild cognitive impairment. Investigators at Brigham and Women's Hospital examined the association of brain amyloid beta and longitudinal measures of depression and depressive symptoms in cognitively normal, older adults. Their findings suggest that higher levels of amyloid beta may be associated with increasing symptoms of anxiety in these individuals. These results support the theory that neuropsychiatric symptoms could be an early indicator of Alzheimer's disease.

Anxiety, risk factor for Alzheimer's disease
"Rather than just looking at depression as a total score, we looked at specific symptoms such as anxiety. When compared to other symptoms of depression such as sadness or loss of interest, anxiety symptoms increased over time in those with higher amyloid beta levels in the brain," said first author Nancy Donovan, MD, a geriatric psychiatrist at Brigham and Women's Hospital. "This suggests that anxiety symptoms could be a manifestation of Alzheimer's disease prior to the onset of cognitive impairment. If further research substantiates anxiety as an early indicator, it would be important for not only identifying people early on with the disease, but also, treating it and potentially slowing or preventing the disease process early on."
Advertisement

Higher brain amyloid beta burden is associated with increasing anxiety symptoms
As anxiety is common in older people, rising anxiety symptoms may prove to be most useful as a risk marker in older adults with other genetic, biological or clinical indicators of high AD risk.

Researchers derived data from the Harvard Aging Brain Study, an observational study of older adult volunteers aimed at defining neurobiological and clinical changes in early Alzheimer's disease. The participants included 270 community dwelling, cognitively normal men and women, between 62 and 90 years old, with no active psychiatric disorders. Individuals also underwent baseline imaging scans commonly used in studies of Alzheimer's disease, and annual assessments with the 30-item Geriatric Depression Scale (GDS), an assessment used to detect depression in older adults.

The team calculated total GDS scores as well as scores for three clusters symptoms of depression: apathy-anhedonia, dysphoria, and anxiety. These scores were looked at over a span of five years.

From their research, the team found that higher brain amyloid beta burden was associated with increasing anxiety symptoms over time in cognitively normal older adults. The results suggest that worsening anxious-depressive symptoms may be an early predictor of elevated amyloid beta levels - and, in turn AD -- and provide support for the hypothesis that emerging neuropsychiatric symptoms represent an early manifestation of preclinical Alzheimer's disease.

Donovan notes further longitudinal follow-up is needed to determine whether these escalating depressive symptoms give rise to clinical depression and dementia stages of Alzheimer's disease over time.

References :
  1. Nancy J. Donovan, Joseph J. Locascio et al. Longitudinal Association of Amyloid Beta and Anxious-Depressive Symptoms in Cognitively Normal Older Adults, American Journal of Psychiatryhttps:doi.org/10.1176/appi.ajp.2017.17040442


Source: Eurekalert

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Get Involved and Stand Up for Human Rights on Human Rights Day 2022
Coronary Artery Bypass Grafting
Macronutrients Calculator for Weight Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anxiety Disorder Agoraphobia Asperger´s Syndrome Stress Relief Through Alternative Medicine Hyperventilation Bereavement Post Traumatic Stress Disorder Xenophobia Tourette Syndrome Placebo Effects: Rare Insights 

Most Popular on Medindia

Blood Donation - Recipients Drug Side Effects Calculator Loram (2 mg) (Lorazepam) Post-Nasal Drip Iron Intake Calculator Daily Calorie Requirements Diaphragmatic Hernia A-Z Drug Brands in India Noscaphene (Noscapine) Sanatogen
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Link Between Anxiety and Alzheimer’s Disease Found Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests